A novel unnatural biflavonoid analog, di(8-daidzeinyl)methane, was synthesized using the C–C coupling reaction of daidzein and formaldehyde catalyzed by aliphatic amine in DMF, and its structure was characterized by ESI-MS, NMR, and FT-IR. Meanwhile, the effect parameters (catalyst, catalyst loading, temperature, and molar ratio of the substrates) were investigated and the optimized reaction conditions obtained using 9 mol % triethylamine as the catalyst, with the reaction run at 80°C for 20 h.
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Acknowledgment
We thank the National Natural Science Foundation of China (No. 21172055), the Natural Science Foundation of the Henan Educational Committee (No. 2011B150007, 12A150007), and the Plan for Scientific Innovation Talent (No. 11CXRC10) and Doctoral Scientific Fund Project of the Henan University of Technology for financial support of this work.
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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2014, pp. 71–73.
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Xiao, YM., Zhu, XL., Yuan, JW. et al. Synthesis and Characterization of Novel Unnatural di(8-Daidzeinyl)Methane. Chem Nat Compd 50, 76–79 (2014). https://doi.org/10.1007/s10600-014-0870-7
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DOI: https://doi.org/10.1007/s10600-014-0870-7