A new stilbene glycoside, 5-methylresveratrol-3,4′-O-β-D-diglucopyranoside (1), was isolated from the n-butanol fraction of the rhizomes of Veratrum dahuricum, together with five known stilbenoids: resveratrol-3-O-β-D-glycoside (2), 4′-methylresveratrol-3-O-β-D-glycoside (3), oxyresveratrol-4′-O-β-D-glycoside (4), oxyresveratrol-3-O-β-D-glycoside (5), and oxyresveratrol-3,4′-O-β-D-diglycoside (6), and found for the first time in the investigated plant. The structures of six isolates were identified on the basis of 1D and 2D NMR data. Compounds 1–6 showed platelet aggregation inhibition, and compound 1 had an IC50 value of 383.6 μM against platelet aggregation induced by AA.
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Acknowledgment
We would like to thank Prof. Yong-Zhen Liu for help in the identification of this plant. The work was supported by the program for Changjiang Scholars and Innovative Research Team in University (PCSIRT), NCET Foundation, NSFC (C03050201), National 863 Program (2006AA02Z338) and in part by the Scientific Foundation of Shanghai China (07DZ19728, 06DZ19717, 06DZ19005).
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Published in Khimiya Prirodnykh Soedinenii, No. 3, pp. 279–282, May–June, 2009.
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Dai, LM., Tang, J., Li, HL. et al. A new stilbene glycoside from the n-butanol fraction of Veratrum dahuricum . Chem Nat Compd 45, 325–329 (2009). https://doi.org/10.1007/s10600-009-9352-8
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DOI: https://doi.org/10.1007/s10600-009-9352-8