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Synthesis of 2-Substituted (2R,4R)-3-(3-Mercapto-Propionyl)Thiazolidine-4-Carboxylic Acids

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Chemistry of Heterocyclic Compounds Aims and scope

The natural amino acid L-cysteine, commercially available aldehydes, and 3-(acetylsulfanyl)propionyl chloride were used for the synthesis of 2-substituted (2R,4R)-3-(3-mercaptopropionyl)thiazolidine-4-carboxylic acids, potential antihypertensive drugs with angiotensin converting enzyme inhibiting action.

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This work received financial support from the Ministry of Education and Science of the Russian Federation (contract 14.ВВВ.21.0008).

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, 31 Bolshoi Ave., Saint Petersburg, 199004, Russia

    A. Yu. Ershov, D. G. Nasledov & V. V. Shamanin

  2. Scientific Research and Testing Center for Biomedical Defense, State Scientific Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation, 4 Lesoparkovaya St., Saint Petersburg, 195043, Russia

    I. V. Lagoda

Authors
  1. A. Yu. Ershov
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  2. D. G. Nasledov
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  3. I. V. Lagoda
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  4. V. V. Shamanin
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Corresponding author

Correspondence to A. Yu. Ershov.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1119-1126, July, 2014.

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Ershov, A.Y., Nasledov, D.G., Lagoda, I.V. et al. Synthesis of 2-Substituted (2R,4R)-3-(3-Mercapto-Propionyl)Thiazolidine-4-Carboxylic Acids. Chem Heterocycl Comp 50, 1032–1038 (2014). https://doi.org/10.1007/s10593-014-1560-x

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  • DOI: https://doi.org/10.1007/s10593-014-1560-x

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