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Quantum-Chemical Analysis of the Algar–Flynn–Oyamada Reaction Mechanism

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Chemistry of Heterocyclic Compounds Aims and scope

This work is devoted to improving the understanding of Algar–Flynn–Oyamada reaction mechanism and the analysis of factors that affect the formation of flavonols. The calculation of thermodynamic parameters for the key reaction steps pointed to a mechanism involving chalcone epoxides as intermediates. A correlation was identified between the nucleophilicity of oxygen atom at position 2' of epoxide anions and the yields of flavonols. An increased charge at the nucleophilic center was shown to reduce the effectiveness of β-cyclization of epoxide anions.

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Authors and Affiliations

  1. Scientific-Research Institute of Chemistry, V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61022, Ukraine

    I. E. Serdiuk & A. D. Roshal

  2. University of Gdańsk, 63 Wita Stwosza St., Gdańsk, 80-308, Poland

    I. E. Serdiuk & J. Błażejowski

Authors
  1. I. E. Serdiuk
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  2. A. D. Roshal
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  3. J. Błażejowski
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Correspondence to J. Błażejowski.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 431-439, March, 2014.

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Serdiuk, I.E., Roshal, A.D. & Błażejowski, J. Quantum-Chemical Analysis of the Algar–Flynn–Oyamada Reaction Mechanism. Chem Heterocycl Comp 50, 396–403 (2014). https://doi.org/10.1007/s10593-014-1487-2

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  • DOI: https://doi.org/10.1007/s10593-014-1487-2

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