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Synthesis of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

The cyclization of 2-substituted N-arylamides of 3-alkylaminobut-2-enethioic acid gave a series of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives containing a benzoyl or ester group at position 4. A study was carried out on the course of this reaction in the presence of various oxidizing agents, including halogens, N-bromosuccinimide, hydrogen peroxide. Some of the isothiazoles obtained in this work exhibited cytotoxic activity against both normal and cancer cell lines.

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Notes

  1. The signal of the (E)-isomer was not seen due to low intensity and broadening.

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga, LV-1006, Latvia

    I. Skrastiņa, A. Baran & D. Muceniece

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  1. I. Skrastiņa
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  2. A. Baran
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  3. D. Muceniece
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Correspondence to I. Skrastiņa.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 669-681, April, 2013.

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Skrastiņa, I., Baran, A. & Muceniece, D. Synthesis of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives. Chem Heterocycl Comp 49, 624–635 (2013). https://doi.org/10.1007/s10593-013-1290-5

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