Cyclocondensation of ethyl 3,3-diaminoacrylate with 5-acetyl-4-chloropyrimidines gave ortho- and peri-condensed heterocycles formed through substitution of the chlorine atom by the α-carbon atom of the enediamine and condensation of the amino group with the carbonyl or by addition of the amino group to the pyridine ring.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 501-506, March 2013.
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Bakulina, O.Y., Igumnova, E.M., Dar’in, D.V. et al. Reaction of ethyl 3,3-diaminoacrylate with pyrimidine series o-chloro ketones. Synthesis of pyrido[4,3-d]pyrimidines and 6H-1,3,6,7-tetra-azaphenalenes. Chem Heterocycl Comp 49, 466–471 (2013). https://doi.org/10.1007/s10593-013-1269-2
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DOI: https://doi.org/10.1007/s10593-013-1269-2