Decarboxylation of substituted monohydrazides of 6-arylcyclohex-3-ene-1,1-dicarboxylic acids proceeds stereospecifically and leads to 1,6-cis-disubstituted cyclohex-3-enes. Due to the presence of the anthranilic acid moiety these decarboxylated hydrazides undergo formation of pyrrolo[1,2-a]quina-zolines when treated with 2-oxoglutaric acid. The present paper describes the first example of chemoselective synthesis of amide-linked conjugates between the cyclohexene moiety and tetrahydro-pyrrolo[1,2-a]quinazolines.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 335–342, February, 2013.
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Zicāne, D., Tetere, Z., Rāviņa, I. et al. Synthesis of Novel 4-Aminotetrahydropyrrolo[1,2-a]quinazoline Derivatives. Chem Heterocycl Comp 49, 310–316 (2013). https://doi.org/10.1007/s10593-013-1248-7
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DOI: https://doi.org/10.1007/s10593-013-1248-7