The condensation reaction of isomeric N-substituted (1H-pyrazol-4-yl)ethanones with the ethyl esters of pyrazole carboxylic acids and fluoroacetic acids has been studied using NaH as the base. Under optimized conditions, it proved to be a convenient and preparative method for the synthesis of N-substituted (1H-pyrazolyl)propane-1,3-diones and (1H-pyrazolyl)-4-polyfluorobutane-1,3-diones.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 843–848, June, 2011.
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Taydakov, I.V., Krasnoselsky, S.S. Modified method for the synthesis of isomeric N-substituted (1H-pyrazolyl)propane-1,3-diones. Chem Heterocycl Comp 47, 695–699 (2011). https://doi.org/10.1007/s10593-011-0821-1
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DOI: https://doi.org/10.1007/s10593-011-0821-1