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Nonalcoholic fatty liver disease: one entity, multiple impacts on liver health

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Abstract

Nonalcoholic fatty liver disease (NAFLD) is very prevalent and now considered the most common cause of chronic liver disease. Staging the severity of liver damage is very important because the prognosis of NAFLD is highly variable. The long-term prognosis of patients with NAFLD remains incompletely elucidated. Even though the annual fibrosis progression rate is significantly higher in patients with nonalcoholic hepatitis (NASH), both types of NAFLD (nonalcoholic fatty liver and nonalcoholic steatohepatitis) can lead to fibrosis. The risk for progressive liver damage and poor outcomes is assessed by staging the severity of liver injury and liver fibrosis. Algorithms (scores) that incorporate various standard clinical and laboratory parameters alongside imaging-based approaches that assess liver stiffness are helpful in predicting advanced fibrosis.

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Authors and Affiliations

  1. Medical Clinic II Gastroenterology, University Hospital Bucharest, Carol Davila University of Medicine and Pharmacy, 7001, Bucharest, Romania

    Carmen Fierbinteanu-Braticevici, Alexandru Moldoveanu, Ana Petrisor & Sorina Diaconu

  2. Department of Cardiology, Bagdasar-Arseni Emergency Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

    Crina Sinescu

  3. Department of Cellular and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474, Bucharest, Romania

    Dragos Cretoiu

  4. Victor Babes National Institute of Pathology, Bucharest, Romania

    Dragos Cretoiu

  5. Theodor Burghele Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

    Bogdan Braticevici

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  1. Carmen Fierbinteanu-Braticevici
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  2. Crina Sinescu
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Fierbinteanu-Braticevici, C., Sinescu, C., Moldoveanu, A. et al. Nonalcoholic fatty liver disease: one entity, multiple impacts on liver health. Cell Biol Toxicol 33, 5–14 (2017). https://doi.org/10.1007/s10565-016-9361-x

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