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Dendritic Amine on Mesoporous Silica: First Organo Base Catalyst for Paal Knorr Reaction under Solvent Free Condition, A green approach

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Abstract

We report for the first time a simple, highly efficient and ecofriendly approach for the preparation of pyrrole derivatives in the presence of dendritic amine grafted on mesoporous silica under solvent free condition. We have synthesized and characterized the three generations of dendritic amine grafted on mesoporous silica (G0–G2) through a stepwise growth technique. The maximum yield was observed with third generation (G2) and the catalyst was easily separated from the reaction mixture. Studies showed that dendritic effect of amino groups on the catalyst was the driving force of the reaction pathway, which has led to the formation of pyrrole derivatives. The green aspect of the present method are use of metal free catalyst, low catalyst loading, shorter reaction times, organic solvents are not needed, facile work-up, purification of the products by non-chromatographic methods, the excellent yield of the products, room temperature and the reusability of the catalyst.

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Acknowledgements

We would like to thank STIC, CUSAT, Dept. of Physics, CUSAT and IIT Delhi for assistance with various analyses. One of the authors (K. A. J) thanks the CSIR, Govt. of India for financial assistance in the form of fellowship.

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Authors and Affiliations

  1. Department of Applied chemistry, Cochin University of Science and Technoogy, Kochi, 682022, Kerala, India

    K. A. Jisha & K. Sreekumar

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  1. K. A. Jisha
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  2. K. Sreekumar
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Correspondence to K. Sreekumar.

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Jisha, K.A., Sreekumar, K. Dendritic Amine on Mesoporous Silica: First Organo Base Catalyst for Paal Knorr Reaction under Solvent Free Condition, A green approach. Catal Lett 147, 964–975 (2017). https://doi.org/10.1007/s10562-017-1975-y

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