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One-Pot Synthesis of 3,4-Dihydro-2(H)-Pyrimidinones Catalyzed by Reusable Acidic Choline-Based Ionic Liquids

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Abstract

A series of choline-based ionic liquids (CIL) have been synthesized in this work. The results suggested that both the cations and the anions have significant influences on their properties such as thermostabilities, acidities and their performances for the synthesis of 3,4-dihydro-2(H)-pyrimidinones. The optimized catalytic system based on the CIL [DMEA][HSO4] for the Biginelli reactions benefits from the wide substrates tolerance, benign reaction conditions, easy work-up procedures, and the feasible reusability of the ionic liquid.

Graphical Abstract

The thermostabilities, acidities, and the catalytic activities for the Biginelli reactions are all follows the sequence of [DMEA][HSO4] > [Choline] [HSO4] > [DMEA][H2PO4] > [Choline] [H2PO4]

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Acknowledgments

This study was supported by the National Natural Science Foundation of China (Grant 20903037, 21172058), and the Research Fund for the Doctoral Program of Higher Education of China (20094104120003).

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, 453007, Henan, People’s Republic of China

    Anlian Zhu, Qianqian Li, Lingjun Li & Jianji Wang

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  1. Anlian Zhu
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  2. Qianqian Li
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  3. Lingjun Li
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  4. Jianji Wang
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Correspondence to Jianji Wang.

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Zhu, A., Li, Q., Li, L. et al. One-Pot Synthesis of 3,4-Dihydro-2(H)-Pyrimidinones Catalyzed by Reusable Acidic Choline-Based Ionic Liquids. Catal Lett 143, 463–468 (2013). https://doi.org/10.1007/s10562-013-0978-6

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