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Hydrogenation of 5-Alkylidene-2,4-Thiazolidiones on Pd/C Catalysts Under Mild Conditions: An Alternative Synthesis Route to Pioglitazone

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Abstract

The hydrogenation of 5-alkylidene-2,4-thiazolidiones was studied using Pd/C to establish an alternative process for pioglitazone synthesis. The reportedly sluggish reactivity was due to the high reaction temperature in formic acid. The conditions were improved to 1 atm at 296 K, which results in a quantitative product with a smaller amount of the catalyst.

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Authors and Affiliations

  1. Graduate School of Material Science, University of Hyogo, 3-2-1 Kohto, Kamigori, Ako-gun, Hyogo, 678-1297, Japan

    Takashi Sugimura, Kanae Oie, Tomonori Misaki & Yasuaki Okamoto

  2. Tsukuba Research Laboratories, Tokuyama Corporation, 40 Wadai, Tsukuba, Ibaraki, 300-4247, Japan

    Kenji Tanaka & Hiroyuki Mori

Authors
  1. Takashi Sugimura
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  2. Kanae Oie
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  3. Tomonori Misaki
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  4. Yasuaki Okamoto
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  5. Kenji Tanaka
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  6. Hiroyuki Mori
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Correspondence to Takashi Sugimura.

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Sugimura, T., Oie, K., Misaki, T. et al. Hydrogenation of 5-Alkylidene-2,4-Thiazolidiones on Pd/C Catalysts Under Mild Conditions: An Alternative Synthesis Route to Pioglitazone. Catal Lett 143, 495–500 (2013). https://doi.org/10.1007/s10562-013-0976-8

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  • DOI: https://doi.org/10.1007/s10562-013-0976-8

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