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Tissue engineering and regenerative medicine in musculoskeletal oncology

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Abstract

Currently used surgical techniques to reconstruct tissue defects after resection of musculoskeletal tumours are associated with high complication rates. This drives a strong demand for innovative therapeutic concepts that are able to improve the clinical outcomes of patients suffering from bone and soft tissue tumours. Tissue engineering and regenerative medicine (TE&RM) provides a technology platform based on biochemical, molecular, cellular and biomaterials modules to selectively direct tissue healing processes for improved defect regeneration. At the same time, precautionary measures have to be taken when these instruments are used in cancer patients to prevent any promotion of tumour growth or metastatic spread. On the other hand, several innovative TE&RM tools are being developed such as multi-functionalized biomaterials, drug-delivering nanomaterials or genetically engineered stem cells that per se have the potential to mediate anti-cancer effects, act synergistically with currently used chemotherapeutics and/or radiotherapy regimens and reduce their side effects. Recently, scientists became conscious that TE&RM strategies may not only be utilized to advance contemporary tissue reconstruction techniques but also to develop personalized diagnostic tools and clinically relevant disease models for cancer patients. Eventually, prospective randomized clinical trials combined with comparative outcome analyses are a conditio sine qua non to shape the benefits of personalized regenerative therapies for the standardized management of patients with musculoskeletal tumours.

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Acknowledgments

BMH and FW are supported by the German Research Foundation (DFG HO 5068/1-1 to BMH and DFG WA 3606/1-1 to FW). BMH and DWH are supported by a project grant from the National Health and Medical Research Council (NHMRC, APP ID 1082313) and an innovator grant from the National Breast Cancer Foundation (NBCF, IN-15-047). DWH is supported by a grant from Worldwide Cancer Research (WWCR, 15-11563).

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Authors and Affiliations

  1. Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD, 4049, Australia

    Boris Michael Holzapfel, Ferdinand Wagner, Laure Christine Martine & Dietmar Werner Hutmacher

  2. Department of Orthopaedic Surgery, University of Wuerzburg, Koenig-Ludwig-Haus, Brettreichstr. 11, 97072, Wuerzburg, Germany

    Boris Michael Holzapfel, Stephan Reppenhagen & Maximilian Rudert

  3. Department of Orthopaedics, University Regensburg, Asklepios Clinic Bad Abbach, Kaiser-Karl V.-Allee 3, 93077, Bad Abbach, Germany

    Ferdinand Wagner

  4. Department of Pediatric Surgery, Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-University Munich, Lindwurmstraße 4, 80337, Munich, Germany

    Ferdinand Wagner

  5. Department of Trauma and Reconstructive Surgery, Center for Musculoskeletal Surgery, Charite University Medicine Berlin, Campus Virchow, Augustenburger Pl. 1, 13353, Berlin, Germany

    Michael Schuetz

  6. School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia

    Jim Denham

  7. Department of Plastic Surgery and Hand Surgery, University Clinic Rechts der Isar, Technical University Munich, Ismaningerstr. 22, 81675, Munich, Germany

    Jan-Thorsten Schantz

  8. School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore

    Jan-Thorsten Schantz

  9. George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive Northwest, Atlanta, GA, 30332, USA

    Dietmar Werner Hutmacher

  10. Institute for Advanced Study, Technical University Munich, Lichtenbergstraße 2a, 85748, Garching, Munich, Germany

    Dietmar Werner Hutmacher

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  1. Boris Michael Holzapfel
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  2. Ferdinand Wagner
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  9. Dietmar Werner Hutmacher
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Correspondence to Boris Michael Holzapfel or Dietmar Werner Hutmacher.

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Holzapfel, B.M., Wagner, F., Martine, L.C. et al. Tissue engineering and regenerative medicine in musculoskeletal oncology. Cancer Metastasis Rev 35, 475–487 (2016). https://doi.org/10.1007/s10555-016-9635-z

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