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The faces and friends of RhoGDI2

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Abstract

RhoGDI2 is a guanine nucleotide dissociation inhibitor (GDI) specific for the Rho family of small GTPases that plays dual opposite roles in tumor progression, being both a promoter in tissues such as breast and a metastasis suppressor in tissues such as the bladder. Despite a clear role for this protein in modulating the invasive and metastatic process, the mechanisms through which RhoGDI2 executes these functions remain unclear. This review will highlight the current state of our knowledge regarding how RhoGDI2 functions in metastasis with a focus on bladder cancer and will also seek to highlight other potential underappreciated avenues through which this protein may affect cancer cell behavior.

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Acknowledgments

This study was supported by National Institutes of Health grants CA143971 to D.T. and CA910935 to E.M.G.

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Authors and Affiliations

  1. Center for Cell Signaling and Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA, 22908, USA

    Erin M. Griner

  2. Department of Pharmacology, University of Colorado, Aurora, CO, 80045, USA

    Dan Theodorescu

  3. University of Colorado Comprehensive Cancer Center, Aurora, CO, 80045, USA

    Dan Theodorescu

  4. Department of Surgery, University of Colorado Comprehensive Cancer Center, Aurora, CO, 80045, USA

    Dan Theodorescu

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Griner, E.M., Theodorescu, D. The faces and friends of RhoGDI2. Cancer Metastasis Rev 31, 519–528 (2012). https://doi.org/10.1007/s10555-012-9376-6

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