Cancer and Metastasis Reviews

, Volume 31, Issue 3, pp 441–454

Diet, nutrients, phytochemicals, and cancer metastasis suppressor genes

Authors

    • Department of Pharmaceutical Sciences, College of PharmacyWashington State University
Article

DOI: 10.1007/s10555-012-9369-5

Cite this article as:
Meadows, G.G. Cancer Metastasis Rev (2012) 31: 441. doi:10.1007/s10555-012-9369-5

Abstract

The major factor in the morbidity and mortality of cancer patients is metastasis. There exists a relative lack of specific therapeutic approaches to control metastasis, and this is a fruitful area for investigation. A healthy diet and lifestyle not only can inhibit tumorigenesis but also can have a major impact on cancer progression and survival. Many chemicals found in edible plants are known to inhibit metastatic progression of cancer. While the mechanisms underlying antimetastatic activity of some phytochemicals are being delineated, the impact of diet, dietary components, and various phytochemicals on metastasis suppressor genes is underexplored. Epigenetic regulation of metastasis suppressor genes promises to be a potentially important mechanism by which dietary components can impact cancer metastasis since many dietary constituents are known to modulate gene expression. The review addresses this area of research as well as the current state of knowledge regarding the impact of diet, dietary components, and phytochemicals on metastasis suppressor genes.

Keywords

CancerDietaryNutrientsPhytochemicalsMetastasis suppressorEpigenetics

Abbreviations

BRMS

Breast cancer metastasis suppressor

CTGF

Connective tissue growth factor

DHA

Docosahexaenoic acid

DLC

Deleted in colon cancer

EGCG

Epigallocatechin-3-gallate

EGF

Epidermal growth factor

EGFR

Epidermal growth factor receptor

EPA

Eicosapentaenoic acid

IFN

Interferon

KAI1

Kangai 1

MALL

Mal-like

MAPK

Mitogen activated protein kinase

MKK

Mitogen-activated protein kinase kinase

miR

Micro RNA

NDRG

N-myc downstream-regulated gene

NM23

Nonmetastatic gene 23

PDCD

Programmed cell death

PEBP

Phosphatidylethanolamine binding protein

PTEN

Phosphatase and tensin homolog

RASSF

Ras-associated domain family

RECK

Reversion-inducing-cysteine-rich protein with kazal motifs

RhoGDI2

Rho GDP-dissociation inhibitor 2

RKIP

Raf-1 kinase inhibitor protein

SNRP

Small nucleolar ribonucleoprotein

TIMP

Tissue inhibitor of metalloproteinase

TRAMP

Transgenic adenocarcinoma of the mouse prostate

Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2012