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Association of hypertension and obesity with renal cell carcinoma risk: a report from the Shanghai Men’s and Women’s Health Studies

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Abstract

Purpose

Consistently reported associations between hypertension and obesity and renal cell carcinoma (RCC) risk have largely come from studies in Western populations. These associations were examined in a case–control study nested in the Shanghai Women’s Health Study (SWHS, 1996–2000) and Shanghai Men’s Health Study (SMHS, 2001–2006).

Methods

Overall, 271 incident RCC cases (124 women, 147 men) were identified through 31 December 2011, and 2,693 controls were individually matched by sex, age, and calendar time at cohort enrollment, and menopausal status (for women). Participants completed a structured questionnaire by in-person interview at baseline, and conditional logistic regression was used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs).

Results

Self-reported hypertension was associated with a significant 40 % increased risk of RCC among women and men (95 % CI 1.1, 1.9). Body mass index (BMI), modeled continuously, was associated with an elevated risk of RCC among men, with an OR of 1.5 (95 % CI 1.1, 2.0) per 5 kg/m2 increase in BMI, but not among women.

Conclusions

Hypertension is independently associated with risk of RCC among both women and men in Shanghai, while overweight and obesity appear to be associated with risk of RCC in Chinese men only.

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Acknowledgments

This work was supported by the Vanderbilt-Shanghai Chronic Disease Research Training Program (Grant D43 TW008213). The Shanghai Women’s Health Study (Grant R37 CA070867) and the Shanghai Men’s Health Study (Grants R01 CA082729, UM1 CA183021) were supported by the National Cancer Institute at the National Institutes of Health.

Conflict of interest

The authors declare that they have no conflict of interests.

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Authors and Affiliations

  1. Division of Epidemiology, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 800, Nashville, TN, 37203-1738, USA

    Tian Shen, Xiao-Ou Shu, Hui Cai, Wei Zheng & Loren Lipworth

  2. Shanghai Cancer Institute, Shanghai, China

    Yong-Bing Xiang, Hong-Lan Li & Yu-Tang Gao

  3. Fudan University School of Public Health, Shanghai, China

    Tian Shen

  4. Shanghai Jiao Tong University School of Public Health, Shanghai, China

    Tian Shen

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  1. Tian Shen
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  2. Xiao-Ou Shu
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  4. Hong-Lan Li
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  7. Wei Zheng
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  8. Loren Lipworth
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Correspondence to Loren Lipworth.

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Shen, T., Shu, XO., Xiang, YB. et al. Association of hypertension and obesity with renal cell carcinoma risk: a report from the Shanghai Men’s and Women’s Health Studies. Cancer Causes Control 26, 1173–1180 (2015). https://doi.org/10.1007/s10552-015-0611-7

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  • DOI: https://doi.org/10.1007/s10552-015-0611-7

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