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ABO blood group and esophageal carcinoma risk: from a case–control study in Chinese population to meta-analysis

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Abstract

Purpose

The association between ABO blood group and the risk of esophageal carcinoma (EC) in previously published studies is uncertain and conflicting. The aim of the current study was to determine the correlation of ABO blood group with EC risk via a case–control study and meta-analysis.

Methods

We performed a population-based case–control study of 3,595 cases and 41,788 controls in Chinese population to evaluate the association between ABO blood group and EC risk. Then, a comprehensive meta-analysis combining our original data and previously published data was conducted to clearly discern the real relationship. The strength of association was measured by odds ratios (ORs) with 95 % confidence intervals (CI).

Results

In our case–control study, the risk of EC in blood group B was significantly higher than that in non-B groups (A, O, and AB) (OR = 1.15, 95 % CI 1.09–1.21). Compared with non-O groups (A, B, and AB), individuals with blood group O demonstrated a reduced risk of EC (OR = 0.90, 95 % CI 0.85–0.94). The meta-analysis also indicated that blood group B was associated with significantly higher EC risk (OR = 1.20, 95 % CI 1.10–1.31), and people with blood group O had a decreased EC risk (OR = 0.94, 95 % CI 0.90–0.99). Neither the case–control study nor the meta-analysis produced any significant association of blood group A or AB with EC risk.

Conclusion

Results from our case–control study and the followed meta-analysis confirmed that there was an increased risk of EC in blood group B individuals, whereas a decreased risk of EC was observed in blood group O individuals.

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Acknowledgments

We gratefully acknowledge the assistance of Songyao Jiang from Department of Surgery, Eastern Hospital, Tongji University, Shanghai, for his skillful technical assistance. This study was supported in part by grant funding of NSFC (Natural Science Foundation of China, 81101847), Doctoral Fund of Ministry of Education of China (20110073120089), project supported by the Shanghai Committee of Science and Technology, China (124119a4801), mandatory project from Nantong Science and Technology Commission (Grant no.: HS2011006).

Conflict of interest

The authors confirm that there are no conflict of interests.

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Authors and Affiliations

  1. Department of Surgery, The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, China

    Wei Wang, Lei Liu, Yixin Zhang, Songqi Jiang, Qiang Wang & Minxin Shi

  2. Department of Surgery, Shanghai Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Zhiwei Wang, Tianlong Lin & Ziang Cao

  3. Department of Blood Management, Nantong Blood Center, Nantong, Jiangsu Province, China

    Xiaopeng Lu

  4. Department of Breast, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China

    Min Wei

Authors
  1. Wei Wang
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  2. Lei Liu
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  3. Zhiwei Wang
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  4. Xiaopeng Lu
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  5. Min Wei
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  6. Tianlong Lin
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  8. Songqi Jiang
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  9. Qiang Wang
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  10. Ziang Cao
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  11. Minxin Shi
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Corresponding authors

Correspondence to Ziang Cao or Minxin Shi.

Additional information

Wei Wang and Lei Liu have contributed equally to this work.

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Wang, W., Liu, L., Wang, Z. et al. ABO blood group and esophageal carcinoma risk: from a case–control study in Chinese population to meta-analysis. Cancer Causes Control 25, 1369–1377 (2014). https://doi.org/10.1007/s10552-014-0442-y

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  • DOI: https://doi.org/10.1007/s10552-014-0442-y

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