Epidemiology

Breast Cancer Research and Treatment

, Volume 110, Issue 1, pp 183-188

Immunohistochemical and molecular subtypes of breast cancer in Nigeria

  • Clement A. AdebamowoAffiliated withDivision of Oncology, Department of Surgery, College of Medicine, University of Ibadan, University College Hospital Email author 
  • , Ayotunde FamootoAffiliated withDivision of Oncology, Department of Surgery, College of Medicine, University of Ibadan, University College Hospital
  • , Temidayo O. OgundiranAffiliated withDivision of Oncology, Department of Surgery, College of Medicine, University of Ibadan, University College Hospital
  • , Toyin AniagwuAffiliated withDivision of Oncology, Department of Surgery, College of Medicine, University of Ibadan, University College Hospital
  • , Chibuzor NkwodimmahAffiliated withDivision of Oncology, Department of Surgery, College of Medicine, University of Ibadan, University College Hospital
  • , Effiong E. AkangAffiliated withDepartment of Pathology, College of Medicine, University of Ibadan, University College Hospital

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Abstract

Objective Previous studies suggest that the majority of breast cancer in Africans are hormone receptor negative and thus differ from breast cancer in other populations. We decided to evaluate the hormone receptor status of patients seen in our practice to see if they indeed differ from that of other populations. Methods We prospectively collected and analyzed tumors from consecutive patients presenting to our clinic over an 18 months period from July 2004. During the period, we saw 192 patients without previous histological diagnosis and conducted routine histological and immunohistochemical analysis of their tumors for hormone receptor status. Results Most, 65.1% of tumors were ER+, 54.7% were PR+ and 79.7% were HER2 negative. Majority of the tumors, 77.6% were luminal type A, 2.6% were luminal type B, 15.8% were basal type and the remaining 4.0% (6/152) were HER2+/ER− subtype. We found an association between hormone receptor status and tumor grade but not with stage at presentation. Conclusion We conclude that there is no difference in the pattern of hormone receptors in breast cancer patients of African origin compared to other populations and urge more use of hormone manipulation for management of breast cancer in this population.

Keywords

Breast cancer ER PR HER2/neu Molecular subtypes Nigeria