We showed the data on clinical efficiency of low doses of antibodies to brain-specific protein S100 in the complex therapy of schoolchildren with painful variant of functional dyspepsia syndrome. Significant positive effects of the substance on the dynamics of epigastric pain, in particular, its duration, were found. The maximum clinical effect was observed in children with emotional disorders (\( \sim \raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$3$}\right. \) of all examined children). Along with significant decrease in frequency appearance and duration of pain syndrome, the substance also normalized emotional state and improved attention concentration in children.
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References
G. Aizenk, and G. Vilson, How to Measure Personality [in Russian], Moscow (2000).
L. I. Aftanas, Emotional Space of a Person: Psychophysiological Analysis [in Russian], Novosibirsk (2000).
E. A. Kornienko, and O. N. Nazhiganov, Pediatriya. Zh. im. G. N. Speranskogo, No. 3, 21-26 (2002).
A. A. Krylova, and S. A. Manicheva, Manual for General Experimental and Applied Psychology [in Russian], St. Petersburg (2002).
V. T. Manchuk, T. V. Polivanova, V. A. Vshivkov, and M. V. Goncharova, Byull. Vost.-Sib. Nauchnogo Tsentra Sib. Otdel. Ross. Akad. Med. Nauk, No. 2-1, 45-49 (2012).
D. V. Pekchurov, P. L. Scherbakov, and T. I. Kaganova, Dyspeptic Disorder in Children [in Russian], Moscow (2007).
T. V. Polivnova, V. T. Manchuk, V. A. Vshivkov, and M. V. Goncharova, Pediatriya. Zh. im. G. N. Speranskogo, 92, No. 6, 135-140 (2013).
O. Yu. Rebrova, Statistical Analysis of Medical Data. Usage of STATISTICA Software Applications Package [in Russian], Moscow (2003).
V. I. Simanenkov, E. G. Poroshina, and S. V. Tikhonov, Bull. Exp. Biol. Med., 148, No. 2, 349-350 (2009).
C. A. Friesen, Z. Lin, R. Garola, et al., Dig. Dis. Sci., 50, No. 6, 1012-1018 (2005).
B. Geeraerts, J. Vandenberghe, L. Van Oudenhove, et al., Gastroenterology, 129, No. 5, 1437-1444 (2005).
J. Tack, N. J. Talley, M. Camilleri, et al., Gastroenterology, 130, No. 5, 1466-1479 (2006).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 319-321, March, 2015
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Polivanova, T.V., Smirnova, O.V., Gorbacheva, N.N. et al. Effi ciency of Very Low Doses of Antibodies to S100 Protein in the Complex Therapy of Functional Dyspepsia in Children. Bull Exp Biol Med 159, 341–343 (2015). https://doi.org/10.1007/s10517-015-2957-y
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DOI: https://doi.org/10.1007/s10517-015-2957-y