Skip to main content
SpringerLink
Log in

Elimination of Iron-Containing Magnetic Nanoparticles from the Site of Injection in Mice: a Magnetic-Resonance Imaging Study

  • Nanotechnologies
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Suspension of magnetic nanoparticles (0.7 g/liter) obtained from Klebsiella oxytoca culture was injected intraperitoneally (1 ml), intramuscularly (in the hip; 100 μl), and subcutaneously (200 μl) or administered orally instead of drinking water for 2 days. The presence of magnetic nanoparticles was evaluated detected by MRI in 15 min and 2 h after injections and in 1 and 2 days after the beginning of oral consumption of the suspension. Magnetic nanoparticles were eliminated from the site of intramuscular and intraperitoneal injections and after oral consumption. The period of elimination after intramuscular and intraperitoneal injections did not exceed 2 h, while after oral consumption it corresponded to the time of gastrointestinal tract contents evacuation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. N. A. Brusentsov, T. N. Brusentsova, E. Yu. Filinova, et al., Khim.-Farm. Zh., 42, No. 4, 3-10 (2008).

    Google Scholar 

  2. K. G. Dobretsov, A. V. Sipkin, S. V. Stolyar, et al., Ross. Rinol., No. 3, 24-25 (2010).

  3. R. A. Rinkk, Magnetic Resonance in Medicine [in Russian], Moscow (2003).

    Google Scholar 

  4. S. V. Stolyar, O. A. Bayukov, Yu. L. Gurevich, et al., Neorgan. Mater., 42, No. 7, 843-848 (2006).

    Google Scholar 

  5. J. W. Bulte and D. L. Kraitchman, NMR Biomed., 17, No. 7, 484-499 (2004).

    Article  CAS  PubMed  Google Scholar 

  6. J. Dobson, Gene Ther., 13, No. 4, 283-287 (2006).

    Article  CAS  PubMed  Google Scholar 

  7. L. A. Ishchenko, S. V. Stolyar, V. P. Ladygina, et al., Phys. Procedia, 9, 279-282 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia

    E. V. Inzhevatkin, V. P. Ladygina & O. V. Falaleev

  2. L. V. Kirensky Institute of Physics, Krasnoyarsk, Russia

    E. V. Morozov & S. V. Stolyar

  3. Nauka Special Designing and Technological Bureau, Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia

    E. V. Morozov

  4. Siberian Federal University, Krasnoyarsk, Russia

    E. V. Inzhevatkin, E. D. Khilazheva & S. V. Stolyar

Authors
  1. E. V. Inzhevatkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. V. Morozov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. D. Khilazheva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. P. Ladygina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. V. Stolyar
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. O. V. Falaleev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. V. Inzhevatkin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 12, pp. 777-781, December, 2014

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Inzhevatkin, E.V., Morozov, E.V., Khilazheva, E.D. et al. Elimination of Iron-Containing Magnetic Nanoparticles from the Site of Injection in Mice: a Magnetic-Resonance Imaging Study. Bull Exp Biol Med 158, 807–811 (2015). https://doi.org/10.1007/s10517-015-2867-z

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-015-2867-z

Key Words

Search

Navigation