Intragastric methionine (3 g/kg daily for 7 days) elevates homocysteine concentration and increases the endothelial dysfunction coefficient. This protocol of methionine treatment is an adequate model of hyperhomocysteine-induced endothelial dysfunction and can be used for studies of the endothelio- and cardioprotective effects of drugs.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 8, pp. 173-175, August, 2011
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Korokin, M.V., Pokrovskiy, M.V., Novikov, O.O. et al. A Model of Hyperhomocysteine-Induced Endothelial Dysfunction in Rats. Bull Exp Biol Med 152, 213–215 (2011). https://doi.org/10.1007/s10517-011-1491-9
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DOI: https://doi.org/10.1007/s10517-011-1491-9