Skip to main content

Advertisement

SpringerLink
Log in

Antiamnestic effect of α7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effects of chronic combined treatment with α7-nicotinic cholinergic receptor agonist RJR-2403 (1.0 mg/kg intraperitoneally) or α7-nicotinic cholinergic receptor antagonist mecamylamine (1.0 mg/kg intraperitoneally) and 17β-estradiol (0.5 µg per rat intramuscularly) for 10 days on passive avoidance retention were studied in middle-aged (15 months) ovariectomized rats with experimental Alzheimer type dementia. Chronic treatment with RJR-2403 and 17β-estradiol had a pronounced antiamnestic effect under conditions of Alzheimer type dementia in middle-aged ovariectomized rats.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. Bures, O. Buresova, and J. P. Houston, Methods and Basic Experiments for Studies of Brain and Behavior [in Russian], Moscow (1991).

  2. Ya. D. Kirshenblat, Endocrinology Practicum [in Russian], Moscow (1969).

  3. V. P. Smetnik, Non-Surgical Gynecology [in Russian], Moscow (2003), pp. 461–474.

  4. R. D. Brinton, Learn. Mem., 8, 121–133 (2001).

    Article  PubMed  CAS  Google Scholar 

  5. E. Fifkova and J. Marsala, Stereotaxic Atlases for the Cat, Rabbit, and Rat Brains, Praha (1960), St. Zdravotnicke Nakald.

  6. R. B. Gibbs, Brain Res., 757, 10–16 (1997).

    Article  PubMed  CAS  Google Scholar 

  7. R. B. Gibbs, Neurosci., 4, 931–938 (2000).

    Article  Google Scholar 

  8. O. A. Levada, Lik. Sprava, 7, 12–16 (2003).

    PubMed  Google Scholar 

  9. R. Lezoualc’h, Y. Sagara, F. Holsboer, and C. Behl, J. Neurosci., 18, 3224–3232 (1998).

    PubMed  CAS  Google Scholar 

  10. E. R. Peskind, J. Clin. Psychiatry, 57, 5–8 (1997).

    Google Scholar 

  11. M. T. Villarroya-Pastor, Rev. Neurol., 32, 1178–1181 (2001).

    PubMed  CAS  Google Scholar 

  12. P. M. Wise, J. Pediatr. Endocrinol. Metab., 13, Suppl. 6, 1425–1429 (2000).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg

    N. S. Sapronov, Yu. O. Fedotova & N. N. Kuznetsova

Authors
  1. N. S. Sapronov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yu. O. Fedotova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. N. Kuznetsova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 12, pp. 656–658, December, 2006

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sapronov, N.S., Fedotova, Y.O. & Kuznetsova, N.N. Antiamnestic effect of α7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia. Bull Exp Biol Med 142, 700–702 (2006). https://doi.org/10.1007/s10517-006-0455-y

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-006-0455-y

Key Words

Search

Navigation