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Previously Undiagnosed HIV Infections Identified Through Cluster Investigation, North Carolina, 2002–2007

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Abstract

During cluster investigation, index patients name social contacts that are not sex or drug-sharing partners. The likelihood of identifying new HIV infections among social contacts is unknown. We hypothesized greater odds of identifying new infections among social contacts identified by men who report sex with men (MSM). We reviewed North Carolina HIV diagnoses during 2002–2005 and used logistic regression to compare testing results among social contacts of MSM, men who report sex with women only (MSW) and women. HIV was newly diagnosed among 54/601 (9.0 %) social contacts tested named by MSM, 16/522 (3.1 %) named by MSW, and 23/639 (3.6 %) named by women. Compared with those named by MSW, odds of new HIV diagnosis were greater among MSM social contacts (adjusted odds ratio: 2.5; 95 % confidence interval: 1.3–4.7). Testing social contacts identified previously undiagnosed HIV infections and could provide an opportunity to interrupt transmission.

Resumen

Durante la investigación de racimo, los pacientes de índice llaman contactos sociales que no son sexuales o comparte drogas a compañeros. La probabilidad de identificar nuevas infecciones de VIH entre contactos sociales es desconocida. Supusimos mayores probabilidades de identificar nuevas infecciones entre contactos sociales identificados por hombres que relatan el sexo con hombres (MSM). Examinamos diagnosticas del VIH de Carolina del Norte durante 2002–2005 y usamos regresión logística para comparar resultados de pruebas entre contactos sociales de MSM, hombres que relatan el sexo con mujeres sólo (MSW) y mujeres. El VIH fue recién diagnosticado entre los 54/601 contactos sociales (9.0 %) llamados por MSM, 16/522 (3.1 %) llamados por MSW y 23/639 (3.6 %) llamados por mujeres. Comparado con aquellos llamados por MSW, las probabilidades del nuevo diagnóstico de VIH eran mayores entre contactos sociales de MSM (proporción de probabilidades ajustada: 2.5; intervalo de confianza del 95 %: 1.3–4.7). Probar contactos sociales identificó infecciones de VIH antes no diagnosticadas y podría proporcionar una oportunidad de interrumpir la transmisión.

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Acknowledgments

The authors thank Michael Hilton, John Barnhart, Todd Vanhoy, and Leigh Cutler of the North Carolina Department of Health and Human Services and Sheryl Lyss with the Centers for Disease Control and Prevention for assistance with obtaining data, review of the article, and assistance with classification of patients.

Disclaimer

The findings and conclusions in this manuscript are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention.

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Authors and Affiliations

  1. Epidemic Intelligence Service, Field Assignments Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA

    Natalie J. M. Dailey Garnes & Betsy L. Cadwell

  2. North Carolina Department of Health and Human Services, Raleigh, NC, USA

    Natalie J. M. Dailey Garnes, Zack S. Moore, Aaron T. Fleischauer & Peter Leone

  3. Career Epidemiology Field Officer Program, Centers for Disease Control and Prevention, Atlanta, GA, USA

    Aaron T. Fleischauer

  4. Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC, USA

    Peter Leone

  5. Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC, USA

    Peter Leone

  6. 1102 Bates Street, Feigin Center, Suite 1120, Houston, TX, 77030, USA

    Natalie J. M. Dailey Garnes

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  1. Natalie J. M. Dailey Garnes
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Correspondence to Natalie J. M. Dailey Garnes.

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Dailey Garnes, N.J.M., Moore, Z.S., Cadwell, B.L. et al. Previously Undiagnosed HIV Infections Identified Through Cluster Investigation, North Carolina, 2002–2007. AIDS Behav 19, 723–731 (2015). https://doi.org/10.1007/s10461-014-0913-x

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  • DOI: https://doi.org/10.1007/s10461-014-0913-x

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