Skip to main content

Advertisement

Log in

Changes in Attitudes Toward Antiviral Medication: A Comparison of Women Living with HIV/AIDS in the Pre-HAART and HAART Eras

  • Behavioral Changes in the Era of Combination Therapies
  • Published:
AIDS and Behavior Aims and scope Submit manuscript

To examine potential changes in attitudes toward antiviral medication since the advent of highly active antiretroviral therapy (HAART), focused interviews were conducted with two samples of women living with HIV/AIDS; one in the pre-HAART era (1994–1996) and a second matched sample in the HAART era (2000–2003). Women in the pre-HAART era held highly negative attitudes toward antiviral medications, perceived them as ineffective with few benefits and viewed side effects as intolerable. In contrast, women in the HAART era were less likely to report negative attitudes, which were balanced by more frequent reports of perceived benefits and more likely to view side effects as temporary and manageable. African American women in both eras were more likely to hold negative attitudes and less likely to perceive benefits than White and Puerto Rican women. These findings suggest that views of antiviral medication have improved since the advent of HAART, but that negative attitudes and side-effect concerns remain which should be addressed in interventions to promote treatment acceptance and adherence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Aversa, S. L., and Kimberlin, C. (1996). Psychosocial aspects of antiretroviral medication use among HIV patients. Patient Education and Counseling, 29, 207–219.

    Article  PubMed  CAS  Google Scholar 

  • Bartlett, J. A. (2002). Addressing the challenges of adherence. Journal of Acquired Immune Deficiency Syndromes, 29(Suppl. 1), S2–S10.

    PubMed  Google Scholar 

  • Bogart, L. M., Catz, S. L., Kelly, J. A., Gray-Bernhardt, M. L., Hartmann, B. R., Otto-Salaj, L. L., Hackl, K. L., and Bloom, F. R. (2000). Psychosocial issues in the era of new AIDS treatments from the perspective of persons living with HIV. Journal of Health Psychology, 5, 500–516.

    Google Scholar 

  • Chesney, M. (2003). Adherence to HAART regimens. AIDS Patient Care and STDs, 17, 169–177.

    Article  PubMed  Google Scholar 

  • Cook, J. A., Cohen, M. H., Grey, D., Kirstein, L., Burke, J., Anastos, K., Palacio, H., Richardson, J., Willson, T. E., and Young, M. (2002). Use of highly active antiretroviral therapy in a cohort of HIV-seropositive women. American Journal of Public Health, 92, 82–87.

    Article  PubMed  Google Scholar 

  • Demas, P., Schoenbaum, E. E., Hirky, A. E., Wills, T. A., Doll, L. S., Hartel, D. M., and Klein, R. S. (1998). The relationship of HIV treatment acceptance and adherence to psychosocial factors among injecting drug users. AIDS and Behavior, 2, 283–292.

    Google Scholar 

  • Demmer, C. (2003). Attitudes toward HIV protease inhibitors and medication adherence in an inner city HIV population. AIDS Patient Care and STDs, 17, 575–580.

    Article  PubMed  Google Scholar 

  • Detels, R., Munoz, A., McFarlane, G., Kingsley, L. A., Margolick, J. B., Giorgi, J., Schrager, L. K., and Phair, J. P. (1998). Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. Journal of the American Medical Association, 280, 1497–1503.

    Article  PubMed  CAS  Google Scholar 

  • Ezzy, D. M., Bartos, M. R., de Visser, R. O., and Rosenthal, D. A. (1998). Antiretroviral uptake in Australia: Medical, attitudinal and cultural correlates. International Journal of STD and AIDS, 9, 579–586.

    Article  PubMed  CAS  Google Scholar 

  • Ferguson, T. F., Stewart, K. E., Funkhouser, E., Tolson, J., Westfall, A. O., and Saag, M. S. (2002). Patient-perceived barriers to antiretroviral adherence: Associations with race. AIDS Care, 14, 607–617.

    Article  PubMed  CAS  Google Scholar 

  • Fogarty, L., Roter, D., Larson, S., Burke, J., Gillespie, J., and Levy, R. (2002). Patient adherence to HIV medication regimens: A review of published and abstract reports. Patient Education and Counseling, 46, 93–108.

    Article  PubMed  Google Scholar 

  • Grierson, J., de Visser, R., and Bartos, M. (2001). More cautious, more optimistic: Australian people living with HIV/AIDS, 1997–1999. International Journal of STD and AIDS, 12, 670–676.

    Article  PubMed  CAS  Google Scholar 

  • Horne, R., Buick, D., Fisher, M., Leake, H., Cooper, V., and Weinman, J. (2004). Doubts about necessity and concerns about adverse effects: Identifying the types of beliefs that are associated with non-adherence to HAART. International Journal of STD and AIDS, 15, 38–44.

    Article  Google Scholar 

  • Kalichman, S. C., Ramachandran, B., and Ostrow, D. (1998). Protease inhibitors and the new AIDS combination therapies: Implications for psychological services. Professional Psychology: Research and Practice, 29, 349–356.

    Article  Google Scholar 

  • Kelly, J. A., Otto-Salaj, L. L., Sikkema, K. J., Pinkerton, S. D., and Bloom, F. R. (1998). Implications of HIV treatment advances for behavioral research on AIDS: Protease inhibitors and new challenges in HIV secondary prevention. Health Psychology, 17, 310–319.

    Article  PubMed  CAS  Google Scholar 

  • McDonald, K., Bartos, M., and Rosenthal, D. (2001). Australian women living with HIV/AIDS are more skeptical than men about antiretroviral treatment. AIDS Care, 13, 15–26.

    Article  PubMed  CAS  Google Scholar 

  • Merton, R. K., Fiske, M., and Kendall, P. L. (1990). The focused interview: A manual of problems and procedures (2nd ed.). New York: Free Press.

    Google Scholar 

  • Mocroft, A., Gill, M. J., Davison, W., and Phillips, A. N. (2000). Are there gender differences in stating protease inhibitors, HAART, and disease progression despite equal access to care? Journal of Acquired Immune Deficiency Syndromes, 24, 475–482.

    PubMed  CAS  Google Scholar 

  • Muhr, T. (1997). ATLAS.ti—Visual qualitative data analysis—Management—Model building—Release 4.1: Short User's Manual (1st ed.). Berlin: Scientific Software Development.

    Google Scholar 

  • Nannis, E. D., Temoshok, L. R., Smith, M., and Jenkins, R. A. (1993). Perceptions of AZT: Implications for adherence to medical regimens. Journal of Applied Biobehavioral Research, 1, 39–54.

    Article  Google Scholar 

  • Oggins, J. (2003). Notions of HIV and medication among multiethnic people living with HIV. Health and Social Work, 28, 53–62.

    Google Scholar 

  • Pach, A., III, Cerbone, F. G., and Gerstein, D. R. (2003). A qualitative investigation of antiretroviral therapy among injection drug users. AIDS and Behavior, 7, 87–100.

    Article  PubMed  Google Scholar 

  • Palella, F. J., Delaney, K., Moorman, A., Loveless, M., Fuhrer, J., Satten, G., Aschman, D., and Holmberg, S. (1998). Declining morbidity and mortality among patients with advanced HIV infection. New England Journal of Medicine, 338, 853–860.

    Article  PubMed  Google Scholar 

  • Powell-Cope, G. M., White, J., Henkelman, E. J., and Turner, B. J. (2003). Qualitative and quantitative assessments of HAART adherence of substance-abusing women. AIDS Care, 15, 239–249.

    Article  PubMed  CAS  Google Scholar 

  • Rabkin, J. G., and Ferrando, S. (1997). A “second life” agenda: Psychiatric research issues raised by protease inhibitor treatments for people with human immunodeficiency virus or the acquired immunodeficiency syndrome. Archives of General Psychiatry, 54, 1049–1053.

    PubMed  CAS  Google Scholar 

  • Sambamoorthi, U., Moynihan, P. J., McSpiritt, E., and Crystal, S. (2001). Use of protease inhibitors and non-nucleoside reverse transcriptase inhibitors among medical beneficiaries with AIDS. American Journal of Public Health, 91, 1474–1481.

    PubMed  CAS  Google Scholar 

  • Siegel, K., and Gorey, E. (1997). HIV-infected women: Barriers to AZT use. Social Science and Medicine, 45, 15–22.

    Article  PubMed  CAS  Google Scholar 

  • Siegel, K., Karus, D., and Schrimshaw, E. W. (2000). Racial differences in attitudes toward protease inhibitors among older HIV-infected men. AIDS Care, 12, 423–434.

    Article  PubMed  CAS  Google Scholar 

  • Siegel, K., Lekas, H.-M., Schrimshaw, E. W., and Johnson, J. K. (2001). Factors associated with HIV-infected women's use or intention to use AZT during pregnancy. AIDS Education and Prevention, 13, 189–206.

    Article  PubMed  CAS  Google Scholar 

  • Smith, M. Y., Rapkin, B. D., Morrison, A., and Kammerman, S. (1997). Zidovudine adherence in persons with AIDS: The relation of patient beliefs about medication to self-termination of therapy. Journal of General Internal Medicine, 12, 216–223.

    Article  PubMed  CAS  Google Scholar 

  • Stone, V. E., Clarke, J., Lovell, J., Steger, K. A., Hirshhorn, L. R., Boswell, S., Monroe, A. D., Stein, M. D., Tyree, T. J., and Mayer, K. H. (1998). HIV/AIDS patients' perspectives on adhering to regimens containing protease inhibitors. Journal of General Internal Medicine, 13, 586–593.

    Article  PubMed  CAS  Google Scholar 

Download references

ACKNOWLEDGMENTS

This research was supported by National Institute of Mental Health Grants MH50414 and MH61148 to Karolynn Siegel (PI). The authors would like to thank Carol Arnold, Laura Dean, Daniel Gardner, Courtney Bradley, and Julie Langsdorf for their assistance in data collection and management. An earlier version of this paper was presented at the annual meeting of the Society for Behavioral Medicine, Boston, MA, April 2005.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eric W. Schrimshaw.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schrimshaw, E.W., Siegel, K. & Lekas, HM. Changes in Attitudes Toward Antiviral Medication: A Comparison of Women Living with HIV/AIDS in the Pre-HAART and HAART Eras. AIDS Behav 9, 267–279 (2005). https://doi.org/10.1007/s10461-005-9001-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10461-005-9001-6

KEY WORDS:

Navigation