Skip to main content

Advertisement

Log in

Sonographically guided puncture of the pancreas: incidence of complications, and risk factors

  • Original Article
  • Published:
Journal of Medical Ultrasonics Aims and scope Submit manuscript

Abstract

Purpose

Data yielded by transabdominal ultrasound-guided puncture techniques are valuable for determining the malignancy of inoperable mass lesions of the pancreas. In this study we analyzed the incidence of complications and the risk factors.

Methods

A total of 430 punctures of the pancreas were performed for 281 patients. Risk factors were prospectively assessed and complications were recorded. All punctures were sonographically guided.

Results

The 281 patients underwent a total of 351 puncture procedures including 430 punctures and 901 passes. The maximum diameter of the pancreatic mass lesion was documented; the mean diameter was 48.3 ± 29.1 mm. 75.8 % of punctures were performed with a needle diameter of 0.7–0.95 mm, and 23.0 % of punctures were performed as cutting biopsies producing a tissue sample 1.2 or 1.6 mm in diameter. In 77.8 % of punctures, one puncture was performed, and in 21.9 %, two punctures were performed. Three punctures were performed for one patient (0.3 %) only. The incidence of major complications was 0.3 %. None of the assessed risk factors was associated with an elevated incidence of complications.

Conclusion

Our findings demonstrate the safety of transabdominal percutaneous puncture of the pancreas but do not enable conclusions to be drawn with regard to individual risk factors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Winter TC, Lee FT Jr, Hinshaw JL. Ultrasound-guided biopsies in the abdomen and pelvis. Ultrasound Q. 2008;24:45–68.

    Article  PubMed  Google Scholar 

  2. Ojalehto M, Tikkakoski T, Rissanen T, et al. Ultrasound-guided percutaneous thoracoabdominal biopsy. Acta Radiol. 2002;43:152–8.

    PubMed  CAS  Google Scholar 

  3. Atwell TD, Gorman B, Larson TS, et al. Pancreas transplants: experience with 232 percutaneous US-guided biopsy procedures in 88 patients. Radiology. 2004;231:845–9.

    Article  PubMed  Google Scholar 

  4. Frieser M, Lindner A, Meyer S, et al. Spectrum and bleeding complications of sonographically guided interventions of the liver and pancreas. Ultraschall Med. 2009;30:168–74.

    Article  PubMed  CAS  Google Scholar 

  5. Hajdu EO, Kumari-Subaiya S, Phillips G. Ultrasonically guided percutaneous aspiration biopsy of the pancreas. Semin Diagn Pathol. 1986;3:166–75.

    PubMed  CAS  Google Scholar 

  6. Klassen DK, Weir MR, Cangro CB, et al. Pancreas allograft biopsy: safety of percutaneous biopsy-results of a large experience. Transplantation. 2002;73:553–5.

    Article  PubMed  Google Scholar 

  7. Malek SK, Potdar S, Martin JA, et al. Percutaneous ultrasound-guided pancreas allograft biopsy: a single-center experience. Transplant Proc. 2005;37:4436–7.

    Article  PubMed  CAS  Google Scholar 

  8. Cadranel JF, Rufat P, Degos F. Practices of liver biopsy in France: results of a prospective nationwide survey. For the Group of Epidemiology of the French Association for the Study of the Liver (AFEF). Hepatology. 2000;32:477–81.

    Article  PubMed  CAS  Google Scholar 

  9. Matsubara J, Okusaka T, Morizane C, et al. Ultrasound-guided percutaneous pancreatic tumor biopsy in pancreatic cancer: a comparison with metastatic liver tumor biopsy, including sensitivity, specificity, and complications. J Gastroenterol. 2008;43:225–32.

    Article  PubMed  Google Scholar 

  10. Soudah B, Fritsch RS, Wittekind C, et al. Value of the cytologic analysis of fine needle aspiration biopsy specimens in the diagnosis of pancreatic carcinomas. Acta Cytol. 1989;33:875–80.

    PubMed  CAS  Google Scholar 

  11. Di Stasi M, Lencioni R, Solmi L, et al. Ultrasound-guided fine needle biopsy of pancreatic masses: results of a multicenter study. Am J Gastroenterol. 1998;93:1329–33.

    Article  PubMed  Google Scholar 

  12. Das DK, Bhambhani S, Kumar N, et al. Ultrasound guided percutaneous fine needle aspiration cytology of pancreas: a review of 61 cases. Trop Gastroenterol. 1995;16:101–9.

    PubMed  CAS  Google Scholar 

  13. Elvin A, Andersson T, Scheibenpflug L, et al. Biopsy of the pancreas with a biopsy gun. Radiology. 1990;176:677–9.

    PubMed  CAS  Google Scholar 

  14. Karlson BM, Forsman CA, Wilander E, et al. Efficiency of percutaneous core biopsy in pancreatic tumor diagnosis. Surgery. 1996;120:75–9.

    Article  PubMed  CAS  Google Scholar 

  15. Al-Kaisi N, Siegler EE. Fine needle aspiration cytology of the pancreas. Acta Cytol. 1989;33:145–52.

    PubMed  CAS  Google Scholar 

  16. Hall-Craggs MA, Lees WR. Fine-needle aspiration biopsy: pancreatic and biliary tumors. AJR Am J Roentgenol. 1986;147:399–403.

    PubMed  CAS  Google Scholar 

  17. Pinto MM, Avila NA, Criscuolo EM. Fine needle aspiration of the pancreas. A five-year experience. Acta Cytol. 1988;32:39–42.

    PubMed  CAS  Google Scholar 

  18. Brandt KR, Charboneau JW, Stephens DH, et al. CT- and US-guided biopsy of the pancreas. Radiology. 1993;187:99–104.

    PubMed  CAS  Google Scholar 

  19. Tillou A, Schwartz MR, Jordan PH Jr. Percutaneous needle biopsy of the pancreas: when should it be performed? World J Surg. 1996;20:283–7.

    Article  PubMed  CAS  Google Scholar 

  20. Zech CJ, Helmberger T, Wichmann MW, et al. Large core biopsy of the pancreas under CT fluoroscopy control: results and complications. J Comput Assist Tomogr. 2002;26:743–9.

    Article  PubMed  Google Scholar 

  21. Terjung B, Lemnitzer I, Dumoulin FL, et al. Bleeding complications after percutaneous liver biopsy. An analysis of risk factors. Digestion. 2003;67:138–45.

    Article  PubMed  Google Scholar 

  22. Sporea I, Popescu A, Sirli R. Why, who and how should perform liver biopsy in chronic liver diseases. World J Gastroenterol. 2008;14:3396–402.

    Article  PubMed  Google Scholar 

  23. Froehlich F, Lamy O, Fried M, et al. Practice and complications of liver biopsy. Results of a nationwide survey in Switzerland. Dig Dis Sci. 1993;38:1480–4.

    Article  PubMed  CAS  Google Scholar 

  24. Thampanitchawong P, Piratvisuth T. Liver biopsy: complications and risk factors. World J Gastroenterol. 1999;5:301–4.

    PubMed  Google Scholar 

  25. Gunneson TJ, Menon KV, Wiesner RH, et al. Ultrasound-assisted percutaneous liver biopsy performed by a physician assistant. Am J Gastroenterol. 2002;97:1472–5.

    Article  PubMed  Google Scholar 

  26. Chuah SY, Moody GA, Wicks AC, et al. A nationwide survey of liver biopsy—is there a need to increase resources, manpower and training? Hepatogastroenterology. 1994;41:4–8.

    PubMed  CAS  Google Scholar 

  27. Chevallier P, Ruitort F, Denys A, et al. Influence of operator experience on performance of ultrasound-guided percutaneous liver biopsy. Eur Radiol. 2004;14:2086–91.

    Article  PubMed  Google Scholar 

  28. Smith EH. Complications of percutaneous abdominal fine-needle biopsy. Review. Radiology. 1991;178:253–8.

    PubMed  CAS  Google Scholar 

  29. Ryd W, Hagmar B, Eriksson O. Local tumour cell seeding by fine-needle aspiration biopsy. A semiquantitative study. Acta Pathol Microbiol Immunol Scand A. 1983;91:17–21.

    PubMed  CAS  Google Scholar 

  30. Fornari F, Civardi G, Cavanna L, et al. Complications of ultrasonically guided fine-needle abdominal biopsy. Results of a multicenter Italian study and review of the literature. The Cooperative Italian Study Group. Scand J Gastroenterol. 1989;24:949–55.

    Article  PubMed  CAS  Google Scholar 

  31. Kim SH, Lim HK, Lee WJ, et al. Needle-tract implantation in hepatocellular carcinoma: frequency and CT findings after biopsy with a 19.5-gauge automated biopsy gun. Abdom Imaging. 2000;25:246–50.

    Article  PubMed  CAS  Google Scholar 

  32. Silva MA, Hegab B, Hyde C, et al. Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis. Gut. 2008;57:1592–6.

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Wolfgang Kratzer.

Additional information

M. Mueller and R. A. Mason contributed equally to this work.

About this article

Cite this article

Mueller, M., Mason, R.A., Kratzer, W. et al. Sonographically guided puncture of the pancreas: incidence of complications, and risk factors. J Med Ultrasonics 40, 19–26 (2013). https://doi.org/10.1007/s10396-012-0376-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10396-012-0376-5

Keywords

Navigation