Skip to main content

Advertisement

Log in

Clinical analysis of the diagnosis and treatment of esophageal perforation

  • Original Article
  • Published:
Esophagus Aims and scope Submit manuscript

Abstract

Background

Despite recent advances in treatment strategies, the management of esophageal perforation is still problematical and controversial. The purpose of the present study was to evaluate and compare the clinical data, treatment methods, and outcomes of patients with esophageal perforation according to the patients’ systemic condition (shock, systemic inflammatory response syndrome (SIRS), or non-SIRS) on arrival to the hospital.

Methods

Twelve patients were treated for an esophageal perforation between 2004 and 2013. Based on the patients’ pretreatment status, the patients were divided into three groups (shock, SIRS, and non-SIRS groups), and their clinical findings, treatment methods, and outcomes were compared.

Results

The numbers of patients in the shock, SIRS, and non-SIRS groups were three, three, and six, respectively. There was a difference in etiologies among the three groups as follows: two patients with spontaneous rupture were in the shock group, two patients with tumor perforation were in the SIRS group, four patients with foreign body were in the non-SIRS group, and patients with iatrogenic causes were included in all groups. The treatment procedures included conservative therapy in 4 non-SIRS patients, primary surgical repair in 4 patients (2 SIRS, 2 non-SIRS), resection in one SIRS patient, and conservative treatment with minor surgical approaches or stenting in 3 shock patients. The mortality rate was 0 %.

Conclusion

Tailoring the treatment strategy to the systemic condition of patients with esophageal perforation is important. In particular, patients with shock should be treated conservatively with minor surgical approaches, including temporary stent insertion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Jones WG 2nd, Ginsberg RJ. Esophageal perforation: a continuing challenge. Ann Thorac Surg. 1992;53:534–43.

    Article  PubMed  Google Scholar 

  2. Reeder LB, De Filippi VJ, Ferguson MK. Current results of therapy for esophageal perforation. Am J Surg. 1995;169:615–7.

    Article  CAS  PubMed  Google Scholar 

  3. Okten I, Cangir AK, Ozdemir N, Kavukçu S, Akay H, Yavuzer S. Management of esophageal perforation. Surg Today. 2001;31:36–9.

    Article  CAS  PubMed  Google Scholar 

  4. Kiernan PD, Rhee J, Collazo L, Byrne WD, Fulcher T, Hettrick V, Vaughan B, Graling P. Thoracic esophageal perforations. South Med. 2003;96:158–63.

    Article  Google Scholar 

  5. Gupta NM, Kaman L. Personal management of 57 consecutive patients with esophageal perforation. Am J Surg. 2004;187:58–63.

    Article  PubMed  Google Scholar 

  6. Jougon J, McBride T, Delcambre F, Minniti A, Velly JF. Primary esophageal repair for Boerhaave’s syndrome whatever the free interval between perforation and treatment. Eur J Cardiothorac Surg. 2004;25:475–9.

    Article  PubMed  Google Scholar 

  7. Zumbro GL, Anstadt MP, Mawulawde K, Bhimji S, Paliotta MA, Pai G. Surgical management of esophageal perforation: role of esophageal conservation in delayed perforation. Am Surg. 2002;68:36–40.

    PubMed  Google Scholar 

  8. Kollmar O, Lindemann W, Richter S, Schilling MK. Boerhaave’s syndrome: primary repair vs. esophageal resection: case reports and meta-analysis of the literature. J Gastrointest Surg. 2003;7:726–34.

    Article  PubMed  Google Scholar 

  9. Martinez L, Rivas S, Hernández F, Avila LF, Lassaletta L, Murcia J, Olivares P, Queizán A, Fernandez A, López-Santamaría M, Tovar JA. Aggressive conservative treatment of esophageal perforations in children. J Pediatr Surg. 2003;38:685–9.

    Article  CAS  PubMed  Google Scholar 

  10. Vogel SB, Rout WR, Martin TD, Abbitt PL. Esophageal perforation in adults: aggressive, conservative treatment lowers morbidity and mortality. Ann Surg. 2005;241:1016–21 (discussion 1021–23).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Furugaki K, Yoshida J, Hokazono K, Emoto T, Nakashima J, Ohyama M, Ishimitsu T, Shinohara M, Matsuo K. Esophageal ruptures: triage using the systemic inflammatory response syndrome score. Gen Thorac Cardiovasc Surg. 2011;59:220–4.

    Article  PubMed  Google Scholar 

  12. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G, SCCM, ESICM, ACCP, ATS, SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med. 2003;31:1250–6.

    Article  PubMed  Google Scholar 

  13. Moy MP, Levsky JM, Berko NS, Godelman A, Jain VR, Haramati LB. A new, simple method for estimating pleural effusion size on CT scans. Chest. 2013;143:1054–9.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Cameron JL, Kieffer RF, Hendrix TR, Mehigan DG, Baker RR. Selective nonoperative management of contained intrathoracic esophageal disruptions. Ann Thorac Surg. 1979;27:404–8.

    Article  CAS  PubMed  Google Scholar 

  15. Larrieu AJ, Kieffer R. Boerhaave syndrome: report of a case treated non-operatively. Ann Surg. 1975;181:452–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Brown RH, Cohne PS. Nonsurgical management of spontaneous esophageal perforation. JAMA. 1978;240:140–2.

    Article  PubMed  Google Scholar 

  17. Darrien JH, Kasem H. Minimally invasive endoscopic therapy for the management of Boerhaave’s syndrome. Ann R Coll Surg Engl. 2013;95:552–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Schweigert M, Beattie R, Solymosi N, Booth K, Dubecz A, Muir A, Moskorz K, Stadlhuber RJ, Ofner D, McGuigan J, Stein HJ. Endoscopic stent insertion versus primary operative management for spontaneous rupture of the esophagus (Boerhaave syndrome): an international study comparing the outcome. Am Surg. 2013;79:634–40.

    PubMed  Google Scholar 

  19. El Hajj II, Imperiale TF, Rex DK, Ballard D, Kesler KA, Birdas TJ, Fatima H, Kessler WR, Dewitt JM. Treatment of esophageal leaks, fistulae, and perforations with temporary stents: evaluation of efficacy, adverse events, and factors associated with successful outcomes. Gastrointest Endosc. 2014;79:589–98.

    Article  PubMed  Google Scholar 

  20. Oshiro T, Kasama K, Umezawa A, Kanehira E, Kurokawa Y. Successful management of refractory staple line leakage at the esophagogastric junction after a sleeve gastrectomy using the HANAROSTENT. Obes Surg. 2010;20:530–4.

    Article  PubMed  Google Scholar 

  21. Inbar R, Santo E, Subchi A-A, Korianski J, Halperin Z, Greenberg R, Avital S. Insertion of removable self-expanding metal stents as a treatment for postoperative leaks and perforations of the esophagus and stomach. Isr Med Assoc J. 2011;13:230–3.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hiroshi Okumura.

Ethics declarations

Ethical Statement

This article does not contain any studies with human or animal subjects performed by any authors.

Conflict of interest

There are no financial or other relations that could lead to a conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Okumura, H., Uchikado, Y., Kita, Y. et al. Clinical analysis of the diagnosis and treatment of esophageal perforation. Esophagus 13, 146–150 (2016). https://doi.org/10.1007/s10388-015-0504-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10388-015-0504-6

Keywords

Navigation