Abstract
Purpose
Acute retinal necrosis (ARN) is a severe necrotizing retinitis caused by varicella-zoster virus or herpes simplex virus (HSV) that often results in blindness. Occasionally, HSV-caused ARN develops after herpes simplex encephalitis (HSE). It remains unknown, however, when and how often ARN develops after HSE. To investigate the actual conditions of patients with ARN following HSE and the interval period between the prior HSE and the onset of ARN, a retrospective nationwide survey of the Japanese population was performed.
Study design
Retrospective.
Methods
Questionnaires were sent out to the neurology and ophthalmology departments of teaching hospitals in Japan. They inquired about HSE patients in neurology departments and ARN patients diagnosed with HSV in ophthalmology departments. The proportion of the HSV-ARN patients with a history of HSE and their interval periods were obtained from the questionnaires returned by the ophthalmology departments.
Results
Neurology departments of 324 hospitals responded to the questionnaires (response proportion: 40.9%), and 53 HSE cases were reported. Ophthalmology departments of 535 hospitals responded the questionnaires (response proportion: 54.3%), and 67 HSV-ARN cases were reported. Among the 67 HSV-ARN cases, 16 (23.9%) had histories of prior HSE. Although the interval periods from the prior HSE to the onset of HSV-ARN varied among cases, nearly half developed HSV-ARN within 2 years.
Conclusions
This nationwide survey of the Japanese population showed that HSV-ARN develops after HSE in higher frequency within 2 years. Neurologists and ophthalmologists should be aware that HSE survivors have a risk of contracting HSV-ARN.
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References
Schoenberger SD, Kim SJ, Thorne JE, Mruthyunjaya P, Yeh S, Bakri SJ, et al. Diagnosis and treatment of acute retinal necrosis: a report by the American Academy of Ophthalmology. Ophthalmology. 2017;124:382–92.
Shahi SK. Acute retinal necrosis results in low vision in a young patient with a history of herpes simplex virus encephalitis. Clin Exp Optom. 2017;100:208–13.
Zhou C, Zhu L, Fang S. Fulminant bilateral acute retinal necrosis syndrome associated with viral encephalitis: a case report. Exp Ther Med. 2016;12:2227–9.
Arruti M, Aldazabal M, Blanco A, Pineiro L, Zapico MS, Gonzalez F, et al. [Acute herpes simplex virus type 1 retinal necrosis three years after herpes simplex encephalitis]. Rev Neurol. 2014;58:45–6.
Sugitani K, Hirano Y, Yasukawa T, Yoshida M, Ogura Y. Unilateral acute retinal necrosis 2 months after herpes simplex encephalitis. Ophthalmic Surg Lasers Imaging. 2010;9:1–5.
Patel P, Ahmed E, Subramanian ML. Intravitreal foscarnet therapy for acyclovir-resistant acute retinal necrosis after herpes simplex encephalitis. Ophthalmic Surg Lasers Imaging. 2010;9:1–3.
Kianersi F, Masjedi A, Ghanbari H. Acute retinal necrosis after herpetic encephalitis. Case Rep Ophthalmol. 2010;1:85–9.
Vandercam T, Hintzen RQ, de Boer JH, Van der Lelij A. Herpetic encephalitis is a risk factor for acute retinal necrosis. Neurology. 2008;71:1268–74.
Yamamoto S, Nakao T, Kajiyama K. Acute retinal necrosis following herpes simplex encephalitis. Arch Neurol. 2007;64:283.
Klein A, Lefebvre P. Three consecutive episodes of acute retinal necrosis due to herpes simplex-1 over twelve years following herpetic encephalitis. Ocul Immunol Inflamm. 2007;15:411–3.
Curtis TH, Mandava N. Acute retinal necrosis as a late sequela of herpes simplex type 1 encephalitis in a child. J AAPOS. 2007;11:509–10.
Bristow EA, Cottrell DG, Pandit RJ. Bilateral acute retinal necrosis syndrome following herpes simplex type 1 encephalitis. Eye (Lond). 2006;20:1327–30.
Whitley RJ. Herpes simplex encephalitis: adolescents and adults. Antiviral Res. 2006;71:141–8.
Solomon T, Michael BD, Smith PE, Sanderson F, Davies NW, Hart IJ, et al. Management of suspected viral encephalitis in adults–Association of British Neurologists and British Infection Association National Guidelines. J Infect. 2012;64:347–73.
Takase H, Okada AA, Goto H, Mizuki N, Namba K, Ohguro N, et al. Development and validation of new diagnostic criteria for acute retinal necrosis. Jpn J Ophthalmol. 2015;59:14–20.
Kamei S, Takasu T. Nationwide survey of the annual prevalence of viral and other neurological infections in Japanese inpatients. Intern Med. 2000;39:894–900.
Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48:452–8.
Raschilas F, Wolff M, Delatour F, Chaffaut C, De Broucker T, Chevret S, et al. Outcome of and prognostic factors for herpes simplex encephalitis in adult patients: results of a multicenter study. Clin Infect Dis. 2002;35:254–60.
Boucher A, Herrmann JL, Morand P, Buzele R, Crabol Y, Stahl JP, et al. Epidemiology of infectious encephalitis causes in 2016. Med Mal Infect. 2017;47:221–35.
Wada-Isoe K, Kusumi M, Kai T, Awaki E, Shimoda M, Yano H, et al. Epidemiological study of acute encephalitis in Tottori Prefecture. Japan. Eur J Neurol. 2008;15:1075–9.
Acknowledgements
We would like to thank all of the doctors who responded to our questionnaires, and Ms. Masumi Ishikawa for her assistance with this survey.
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D.Todokoro, None; S.Kamei, None; H.Goto, None; Y.Ikeda, None; H.Koyama, None; H.Akiyama, None.
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Corresponding author: Daisuke Todokoro
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Todokoro, D., Kamei, S., Goto, H. et al. Acute retinal necrosis following herpes simplex encephalitis: a nationwide survey in Japan. Jpn J Ophthalmol 63, 304–309 (2019). https://doi.org/10.1007/s10384-019-00668-5
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DOI: https://doi.org/10.1007/s10384-019-00668-5