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Characteristic correlations of the structure-function relationship in different glaucomatous disc types

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the influence of the optic disc type on the overall and regional correlation between structure and function in open angle glaucoma (OAG).

Methods

We divided 144 eyes of 144 patients with OAG into four groups according to Nicolela et al.’s classification of optic disc type: focal ischemic (FI), myopic glaucomatous (MY), senile sclerotic (SS), and generalized enlargement (GE). We measured the circumpapillary retinal nerve fiber layer thickness (cpRNFLT) with the 3D OCT-2000 and the mean deviation (MD) with the Humphrey Field Analyzer in each group and determined the influence of the disc type on these parameters with the Spearman rank correlation.

Results

We found that cpRNFLT and MD were significantly correlated in the MY (r = 0.61, P < 0.001), GE (r = 0.62, P < 0.001), and SS groups (r = 0.52, P = 0.002), but not in the FI group (r = 0.25, P = 0.130). The region of the optic disc with the highest correlation coefficient between structure and function differed according to the disc type.

Conclusions

The correlation between cpRNFLT and MD varied according to the optic disc morphology in OAG. This suggests that different disc types have characteristic regional variations in the correlation between structure and function. The disc type should therefore be considered in investigations of the correlation between structure and function in glaucoma.

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Acknowledgments

The authors thank Drs. Yukihiro Shiga, Yu Yokoyama, and Satoru Tsuda for collecting the patient data used in this study and Mr. Tim Hilts for editing the manuscript. This study was supported in part by a JST grant from JSPS KAKENHI Grants-in-Aid for Scientific Research (B) (T.N., 26293372) and for Exploratory Research (T.N., 26670751) and by the JST Center for Revitalization Promotion.

Conflicts of interest

K. Omodaka, None; N. Takada, None; T. Yamaguchi, None; H. Takahashi, None; M. Araie, None; T. Nakazawa, None.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan

    Kazuko Omodaka, Naoko Takada, Hidetoshi Takahashi & Toru Nakazawa

  2. Division of Biostatistics, Tohoku University Graduate School of Medicine, Sendai, Japan

    Takuhiro Yamaguchi

  3. Department of Ophthalmology, Kanto Central Hospital, Tokyo, Japan

    Makoto Araie

  4. Department of Retinal Disease Control, Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan

    Toru Nakazawa

  5. Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

    Toru Nakazawa

Authors
  1. Kazuko Omodaka
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  2. Naoko Takada
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  3. Takuhiro Yamaguchi
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  4. Hidetoshi Takahashi
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  5. Makoto Araie
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  6. Toru Nakazawa
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Corresponding author

Correspondence to Toru Nakazawa.

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Omodaka, K., Takada, N., Yamaguchi, T. et al. Characteristic correlations of the structure-function relationship in different glaucomatous disc types. Jpn J Ophthalmol 59, 223–229 (2015). https://doi.org/10.1007/s10384-015-0379-z

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  • DOI: https://doi.org/10.1007/s10384-015-0379-z

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