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Acute retinal necrosis: factors associated with anatomic and visual outcomes

  • Clinical Investigation
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Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To examine the factors associated with anatomic and visual outcomes in Japanese patients with acute retinal necrosis (ARN).

Methods

One hundred four patients with ARN who were followed for more than 1 year at nine referral centers were reviewed. Retinal involvement at initial presentation was classified into four groups: zone 1 (posterior pole, n = 22), zone 2 (midperiphery, n = 54), zone 3 (periphery, n = 25), and unknown (n = 3). Forty-eight eyes underwent prophylactic vitrectomy before development of retinal detachment (vitrectomy group); 56 eyes were treated conventionally without prophylactic vitrectomy (observation group).

Results

The retina was attached in 28 of 48 eyes (58.3 %) in the vitrectomy group and 42 of 56 eyes (75.0 %) in the observation group at the final visit (P = 0.071). At 1 year, 56 eyes (53.8 %) had a best-corrected visual acuity (BCVA) of 20/200 or worse. Multivariate logistic regression analyses identified zone 1 disease (odds ratio = 4.983) and optic nerve involvement (odds ratio = 5.084) as significantly associated with BCVA of 20/200 or worse. Among the zone 3 eyes, significantly (P = 0.012) more eyes in the observation group than in the vitrectomy group had an attached retina.

Conclusions

Prophylactic vitrectomy did not improve the final BCVA in any eyes. Zone 3 eyes had better outcomes without prophylactic vitrectomy.

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Acknowledgments

The authors thank Hiroshi Keino and Takayo Watanabe (Kyorin University School of Medicine), Kimiko Okinaga (the University of Tokyo), and Norihiko Ito (Yokohama City University) for data collection.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan

    Chiharu Iwahashi-Shima & Nobuyuki Ohguro

  2. Department of Ophthalmology, Kobe University School of Medicine, Kobe, Japan

    Atsushi Azumi

  3. Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan

    Annabelle A. Okada

  4. Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan

    Toshikatsu Kaburaki

  5. Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan

    Hiroshi Goto

  6. Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Koh-Hei Sonoda

  7. Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan

    Koh-Hei Sonoda

  8. Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Kenichi Namba

  9. Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Nobuhisa Mizuki

  10. Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

    Manabu Mochizuki

  11. Department of Ophthalmology, Osaka Koseinenkin Hospital, 4-2-78 Fukushima, Fukushima-ku, Osaka, 553-0003, Japan

    Nobuyuki Ohguro

Authors
  1. Chiharu Iwahashi-Shima
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  2. Atsushi Azumi
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  3. Nobuyuki Ohguro
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  4. Annabelle A. Okada
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  5. Toshikatsu Kaburaki
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  6. Hiroshi Goto
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  7. Koh-Hei Sonoda
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  8. Kenichi Namba
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  9. Nobuhisa Mizuki
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  10. Manabu Mochizuki
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Corresponding author

Correspondence to Nobuyuki Ohguro.

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Iwahashi-Shima, C., Azumi, A., Ohguro, N. et al. Acute retinal necrosis: factors associated with anatomic and visual outcomes. Jpn J Ophthalmol 57, 98–103 (2013). https://doi.org/10.1007/s10384-012-0211-y

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  • DOI: https://doi.org/10.1007/s10384-012-0211-y

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