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Vitreous inflammatory factors in macular edema with central retinal vein occlusion

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the correlation of soluble intercellular adhesion molecule 1 (sICAM-1) and vascular endothelial growth factor (VEGF) with macular edema in patients with central retinal vein occlusion (CRVO).

Methods

Twenty-nine patients who had CRVO with macular edema and 16 patients with non-ischemic ocular diseases (control group) participated. Retinal ischemia was evaluated by measuring the area of capillary non-perfusion with fluorescein angiography and the public domain Scion Image program. Macular edema was examined by optical coherence tomography. Vitreous samples were obtained during pars plana vitrectomy. VEGF and sICAM-1 levels in vitreous fluid and plasma were determined by enzyme-linked immunosorbent assay.

Results

The median vitreous levels of VEGF and sICAM-1 were significantly higher in the CRVO patients than in the control group [366 vs. 15.6 pg/ml (P < 0.001) and 20.5 vs. 5.0 ng/ml (P < 0.001), respectively]. Vitreous levels of both VEGF and sICAM-1 were also significantly higher in the CRVO patients who had retinal ischemia than in those without ischemia (P < 0.001 and P = 0.011, respectively). Vitreous levels of VEGF and sICAM-1 were also significantly correlated with the severity of macular edema (P = 0.004 and P = 0.012, respectively).

Conclusions

VEGF and sICAM-1 may both increase vascular permeability in CRVO patients with macular edema, with sICAM-1 acting together with and/or via VEGF.

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Acknowledgments

The authors indicate that there was no financial support and there are no financial conflicts of interest. We thank Mr. Katsunori Shimada (Department of Biostatistics, STATZ Corporation, Tokyo) for assistance with the statistical analysis.

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Authors and Affiliations

  1. Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women’s Medical University, 477-96 Owada-shinden, Yachiyo, Chiba, 276-8524, Japan

    Hidetaka Noma & Hideharu Funatsu

  2. Department of Ophthalmology, Yodogawa Christian Hospital, Osaka, Japan

    Seiyo Harino

  3. Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan

    Tatsuya Mimura

  4. Department of Ophthalmology, Eguchi Eye Hospital, Hakodate, Japan

    Shuichiro Eguchi

  5. Department of Ophthalmology, Tokyo Women’s Medical University, Tokyo, Japan

    Sadao Hori

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  1. Hidetaka Noma
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  2. Hideharu Funatsu
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  3. Seiyo Harino
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  4. Tatsuya Mimura
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  5. Shuichiro Eguchi
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Correspondence to Hidetaka Noma.

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Noma, H., Funatsu, H., Harino, S. et al. Vitreous inflammatory factors in macular edema with central retinal vein occlusion. Jpn J Ophthalmol 55, 248–255 (2011). https://doi.org/10.1007/s10384-011-0016-4

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  • DOI: https://doi.org/10.1007/s10384-011-0016-4

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