Abstract
Background
To report the changes in the optical coherence tomography (OCT) images of the outer retinal layers after prolonged dark adaptation in a patient with Oguchi disease.
Case
A 75-year-old woman showed the typical golden-yellow fundus reflex of Oguchi disease, and the coloration returned to normal after prolonged dark adaptation. Fourier domain OCT (FD-OCT) was performed on the patient’s left eye before and after prolonged dark adaptation.
Observations
Before dark adaptation, the FD-OCT images at the fovea had three identifiable reflection bands, namely, the external limiting membrane (ELM), the border between the photoreceptor inner and outer segments (IS/OS line), and the retinal pigment epithelium (RPE)/Bruch band. The paramacular area had only the ELM and RPE/Bruch bands. After 4 h of dark adaptation, the IS/OS line was also detected in the paramacular area.
Conclusions
The absence of the IS/OS line in the extramacular regions in the partly dark adapted condition was most likely due to a defect in the rod photoreceptors of this area. The emergence of the IS/OS line after prolonged dark adaptation suggests that microarchitectural changes occur in the photoreceptors and that the changes may be correlated with the improvement of rod function.
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Yamada, K., Motomura, Y., Matsumoto, C.S. et al. Optical coherence tomographic evaluation of the outer retinal architecture in Oguchi disease. Jpn J Ophthalmol 53, 449–451 (2009). https://doi.org/10.1007/s10384-009-0708-1
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DOI: https://doi.org/10.1007/s10384-009-0708-1