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Actovegin®: a biological drug for more than 5 decades

Actovegin®: ein Biologikum seit mehr als 5 Dekaden

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An Erratum to this article was published on 01 February 2011

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Zusammenfassung

Actovegin® ist ein biologisches Pharmakon, das von einer natürlichen Quelle stammt: es handelt sich um ein Kälberblut-Hämidialysat. Seine therapeutischen Vorzüge rühren von unterschiedlichen pharmakodynamischen Aktivitäten her, die eine gemeinsame Zielrichtung verfolgen, nämlich die Verbesserung des zellulären Stoffwechsels. Dies resultiert von einer Insulin-artigen Aktivität die von Inositol-phospho-oligosacchariden mediiert wird. Actovegin® erzielt günstige Effekte in verschiedenen pathophysiologischen klinischen Situationen; hierzu zählen Fehlfunktionen der Blutzirkulation und verwandter Erkrankungen, Hauttransplantationen sowie akute und chronische Wunden. In diesem Übersichtsartikel fassen wir die unterschiedlichen pharmakodynamischen Wirkungen des Kälberblut-Hemidialysats und seine wesentlichen klinischen Wirkungen zusammen.

Summary

Actovegin® is a biological drug manufactured from a natural source: it is a calf blood hemodialysate. Its therapeutic benefits stem from a variety of pharmacodynamic actions that can be summarized to a common goal, i.e. the enhancement of cellular metabolism; this results from an insulin-like activity mediated by Inositol-phospho-oligosaccharides. Actovegin® results in beneficial effects in several pathophysiological clinical settings including malfunction of the blood circulation and trophic disturbances in the brain, impairment of peripheral blood circulation and associated diseases, dermal transplants and acute and chronic wounds. Here, we give an overview of the pharmacodynamic actions of calf-blood hemidialysate and its beneficial effects in a variety of clinical settings.

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Authors and Affiliations

  1. Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, Vienna, Austria

    Florian Buchmayer, Gerfried Nell & Harald H. Sitte

  2. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

    Johannes Pleiner

  3. Nycomed GmbH, Biomarker Development, Konstanz, Germany

    Martin W. Elmlinger & Gereon Lauer

Authors
  1. Florian Buchmayer
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  2. Johannes Pleiner
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  3. Martin W. Elmlinger
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  4. Gereon Lauer
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  5. Gerfried Nell
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  6. Harald H. Sitte
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Correspondence to Harald H. Sitte.

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Buchmayer, F., Pleiner, J., Elmlinger, M. et al. Actovegin®: a biological drug for more than 5 decades. Wien Med Wochenschr 161, 80–88 (2011). https://doi.org/10.1007/s10354-011-0865-y

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  • DOI: https://doi.org/10.1007/s10354-011-0865-y

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