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Effects of Caffeine on Anorectal Manometric Findings

  • Original Contribution
  • Published:
Diseases of the Colon & Rectum

Abstract

Purpose

This study was designed to evaluate the effects of caffeine on anorectal function by anorectal manometry.

Methods

Ten healthy subjects were studied. They drank 200 ml of water and later 200 ml of a solution that contained caffeine 3.5 mg/kg body weight. The anorectal manometric study was divided into three periods: basal, water, and caffeine; each period lasted 45 minutes.

Results

After the ingestion of water, the basal anal sphincter pressure showed no change during the 45-minute recording, whereas after caffeine consumption the basal anal sphincter pressure increased at 10 minutes (P = 0.047) and 15 minutes (P = 0.037). The average basal anal sphincter pressure throughout the 45 minutes was significantly higher after caffeine ingestion than after water (P = 0.013). After caffeine intake, the maximum squeeze pressure increased significantly (P = 0.017) compared with the basal period. Both water and caffeine consumption caused a decrease in the rectal sensory threshold for the desire to defecate.

Conclusions

Caffeine 3.5 mg/kg body weight in 200 ml of water resulted in stronger anal sphincter contractions both at basal period and during voluntary squeeze. The sensory threshold was also decreased, leading to an earlier desire to defecate. Caffeine consumption may result in an earlier desire to defecate, leading to defecation if the anal sphincter can relax voluntarily.

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References

  1. Boekema PJ, Samsom M, van Berge Henegouwen GP, Smout AJ. Coffee and gastrointestinal function: facts and fiction. A review. Scan J Gastroenterol Suppl 1999;230:35–9.

    Article  CAS  Google Scholar 

  2. Brown SR, Cann PA, Read NW. Effect of coffee on distal colon function. Gut 1990;31:450–3.

    Article  PubMed  CAS  Google Scholar 

  3. Butcher RE, Vorhees CV, Wootten V. Behavioral and physical development of rats chronically exposed to caffeinated fluids. Fundam Appl Toxicol 1984;4:1–13.

    Article  PubMed  CAS  Google Scholar 

  4. Hughes RN, Beveridge IJ. Behavioral effect of exposure to caffeine during gestation, lactation or both. Neurotoxicol Teratol 1991;13:641–7.

    Article  PubMed  CAS  Google Scholar 

  5. Metcalf A. Anorectal disorders. Five common causes of pain, itching, and bleeding. Postgrad Med 1995;98:81–94.

    PubMed  CAS  Google Scholar 

  6. Lohsiriwat S, Puengna N, Leelakusolvong S. Effect of caffeine on lower esophageal sphincter pressure in Thai healthy volunteers. Dis Esophagus 2006;19:183–8.

    Article  PubMed  CAS  Google Scholar 

  7. Lopez-Galilea I, Pena PD, Cid C. Correlation of selected constituents with the total antioxidant capacity of coffee beverages: influence of the brewing procedure. J Agric Food Chem 2007;55:6110–7.

    Article  PubMed  CAS  Google Scholar 

  8. Magkos F, Kavouras SA. Caffeine use in sports, pharmacokinetics in man, and cellular mechanisms of action. Crit Rev Food Sci Nutr 2005;45:535–62.

    Article  PubMed  CAS  Google Scholar 

  9. Rao SS, Welcher K, Zimmerman B, Stumbo P. Is coffee a colonic stimulant? Eur J Gastroenterol Hepatol 1998;10:113–8.

    Article  PubMed  CAS  Google Scholar 

  10. Tanavi A, Vecchia CL. Coffee, decaffeinated coffee, tea and cancer of the colon and rectum: a review of epidemiological studies, 1990–2003. Cancer Cause Control 2004;15:743–57.

    Article  Google Scholar 

  11. Abo M, Kono T, Lu CL, Chen JD. Effects of caffeine on gastrointestinal myoelectric activity and colonic spike activity in dogs. Scand J Gastroenterol 2000;35:368–74.

    Article  PubMed  CAS  Google Scholar 

  12. Simpson RR, Kennedy ML, Nguyen MH, Dinning PG, Lubowski DZ. Anal manometry: a comparison of techniques. Dis Colon Rectum 2006;49:1–6.

    Article  Google Scholar 

  13. Michels KB, Willett WC, Fuchs CS, Giovannucci E. Coffee, tea, and caffeine consumption and incidence of colon and rectal cancer. J Natl Cancer Inst 2005;97:282–92.

    Article  PubMed  CAS  Google Scholar 

  14. Siproudhis L, Pigot F, Godeberge P, Damon H, Soudan D, Bigard MA. Defecation disorders: a French population survey. Dis Colon Rectum 2006;49:219–27.

    Article  PubMed  Google Scholar 

  15. Sloots CE, Felt-Bersma RJ, West RL, Kuipers EJ. Stimulation of defecation: effects of coffee use and nicotine on rectal tone and visceral sensitivity. Scand J Gastroenterol 2005;40:808–13.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Prannok Road, Bangkok, 10700, Thailand

    Supatra Lohsiriwat M.D. & Pahurat Kongmuang M.Sc.

  2. Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Somchai Leelakusolvong M.D.

Authors
  1. Supatra Lohsiriwat M.D.
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  2. Pahurat Kongmuang M.Sc.
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  3. Somchai Leelakusolvong M.D.
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Correspondence to Supatra Lohsiriwat M.D..

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Lohsiriwat, S., Kongmuang, P. & Leelakusolvong, S. Effects of Caffeine on Anorectal Manometric Findings. Dis Colon Rectum 51, 928–931 (2008). https://doi.org/10.1007/s10350-008-9271-y

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  • DOI: https://doi.org/10.1007/s10350-008-9271-y

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