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Voxel-based mapping of five MR biomarkers in the wrist bone marrow

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Abstract

Objective

MRI is a reliable and accurate technique to characterize rheumatoid arthritis. The aim of this study was to provide voxel-by-voxel 3D maps of the proton density fat fraction (PDFF), the T1 of water (T1W), the T1 of fat (T1F), the T2* of water (T2*W), the T2* of fat (T2*F) in the wrist bone marrow.

Materials and methods

The experiments were conducted on 14 healthy volunteers (mean age: 24 ± 4). The data were acquired at 1.5 T using two optimized four-echo 3D 1.2 × 1.2 × 1.2 mm3-isotropic spoiled gradient sequences. A repeatability study was carried out. The measurements were done using a homemade parametric viewer software.

Results

The inter-volunteer results were, on average: PDFF = 86 ± 3%, T1W = 441 ± 113 ms, T1F = 245 ± 19 ms, T2*W = 6 ± 1 ms and T2*F = 16 ± 3 ms. The coefficients of variation were for fat based biomarkers CVPDFF < 5%, CVT1F < 15% and CVT2*F < 10% in the repeatability study.

Discussion

The protocol and quantification tool proposed in this study provide high-resolution voxel-by-voxel 3D maps of five biomarkers in the wrist in less than 4 min of acquisition.

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Acknowledgements

The authors would thank the radiographers and technicians of Rennes University Hospital (Hôpital Sud) for their kind support. The volunteers were included in the OSS-IRM study, supported by the University Hospital of Rennes and the University of Rennes. The authors would like to thank Lauren Langford and John Delayre for proofreading the manuscript.

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Authors and Affiliations

  1. CLCC Eugène Marquis, Inserm, LTSI - UMR 1099, Univ Rennes, CHU Rennes, 2 Av. du Professeur Léon Bernard, 35000, Rennes, France

    Louis Marage, Jeremy Lasbleiz, Maxime Fondin, Mathieu Lederlin, Giulio Gambarota & Hervé Saint-Jalmes

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  1. Louis Marage
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  2. Jeremy Lasbleiz
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Correspondence to Louis Marage.

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The acquisitions performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee (Comité Protection des Personnes Ouest V, Rennes, France) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Marage, L., Lasbleiz, J., Fondin, M. et al. Voxel-based mapping of five MR biomarkers in the wrist bone marrow. Magn Reson Mater Phy 34, 729–740 (2021). https://doi.org/10.1007/s10334-020-00901-0

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