Abstract
The histopathological, immunohistochemical, and ultrastructural morphologic characteristics of a tumor in the subcutaneous tissue of the chest of a 19-year-old female Japanese macaque were investigated. Consequently, the mass was diagnosed as a malignant mast cell tumor (MCT). Tumors were present in both mammary gland portions of the anterior thorax. Both tumors showed the same histopathological findings. The tumor tissue was defined by the presence of delicate connective tissue, and the tumor cells grew in a cord-like or cobblestone pattern. The tumor cell cytoplasm was very clear. The nuclei were relatively uniform and the cells showed a low nucleus-cytoplasm ratio. The cytoplasmic granules stained blue with Alcian blue and eosinophils had infiltrated into the tumor tissue. Furthermore, immunohistochemical analysis revealed that the tumor cell membrane was positive for the anti-c-kit antibody. In ultrastructural morphologic analyses, all tumor cells showed a rich cytoplasm and, occasionally, granules wrapped in a limiting membrane of high electron density. The tumor cells had metastasized to the axillary lymph nodes, the kidney, and the peritoneum. Based on these results, the mass was diagnosed as a malignant MCT originating from the subcutaneous tissue of the chest. Since cases of MCTs in macaques are very rare, this report presents important new knowledge of neoplastic lesions in this species.
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References
Bliss EL, Iverson WO (1981) Mastocytomas in the dairy cow: two case reports. Vet Med Small Anim Clin 76:79–81
Bonadonna P, Lombardo C, Zanotti R (2014) Mastocytosis and allergic diseases. J Investig Allergol Clin Immunol 24:288–297; quiz 3 p preceding 297
Butterfield JH (2006) Systemic mastocytosis: clinical manifestations and differential diagnosis. Immunol Allergy Clin North Am 26:487–513
Chott A, Guenther P, Huebner A, Selzer E, Parwaresch RM, Horny HP, Valent P (2003) Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma. Am J Surg Pathol 27:1013–1019
Colgin LM, Moeller RB (1996) Benign cutaneous mast cell tumor in a rhesus monkey. Lab Anim Sci 46:123–124
Dallwig RK, Whittington JK, Terio K, Barger A (2012) Cutaneous mast cell tumor and mastocytosis in a black-masked lovebird (agapornis personata). J Avian Med Surg 26:29–35
Fujimoto A, Wada Y, Kanada T, Ishikawa Y, Kadota K (2012) Mast cell sarcoma with megakaryocytic differentiation in a calf. J Vet Med Sci 74:1643–1646
Goldschmidt MH, Hendrick MJ (2002) Tumors of the skin and soft tissues. In: Meuten DJ (ed) Tumors in Domestic Animals. 4th edn. Iowa State Press, Ames, pp 45–117
Gross TL, Ihrke PJ, Walder EJ, Affolter VK (2005) Mast cell tumors. In: Skin diseases of the dog and cat: clinical and histopathological diagnosis, 2nd edn, Wiley-Blackwell, Oxford, pp 853–865
Hendrick MJ, Mahaffey FM, Moore MJ, Vos JH, Walder EJ (1998) Mast cell tumors. In: Schulman FY (ed) World Health Organization International Classification of tumors of domestic animals, histological classification of mesenchymal tumors of skin and soft tissues of domestic animals, 2nd series, vol 2. Armed Forces Institute of Pathology, Washington, D. C., pp 28–29
Ishida M, Iwai M, Kagotani A, Iwamoto N, Okabe H (2014) Cutaneous mastocytosis with abundant eosinophilic infiltration: a case report with review of the literature. Int J Clin Exp Pathol 7:2695–2697
Jones SR, MacKenzie WF, Robinson FR (1974) Comparative aspects of mastocytosis in man and animals with report of a case in a baboon. Lab Anim Sci 24:558–562
Lee Y, Wood P, Soyer HP (2013) Indolent systemic mastocytosis: a case and review of the current available treatment options. Dermatol Online J 19:18562
Lin TY, Hamberg A, Pentecost R, Wellman M, Stromberg P (2010) Mast cell tumors in a llama (lama glama). J Vet Diagn Invest 22:808–811
London CA, Seguin B (2003) Mast cell tumors in the dog. Vet Clin North Am Small Anim Pract 33:473–489
Martinez J, Martinez V, Grau-Roma L, Lopez J, Segales J (2011) Multiple cutaneous mast cell tumors in a pig. J Vet Diagn Invest 23:1222–1225
Morini M, Bettini G, Preziosi R, Mandrioli L (2004) C-kit gene product (CD117) immunoreactivity in canine and feline paraffin sections. J Histochem Cytochem 52:705–708
Pardanani A (2015) Systemic mastocytosis in adults: 2015 update on diagnosis, risk stratification, and management. Am J Hematol 90:250–262
Patnaik AK, Ehler WJ, MacEwen EG (1984) Canine cutaneous mast cell tumor: morphologic grading and survival time in 83 dogs. Vet Pathol 21:469–474
Patrascu V, Enache AO, Ciurea RN, Georgescu CC, Vilcea AM, Stoica LE, Ciurea ME (2014) Cutaneous mastocytosis, problems of clinical diagnosis of four cases. Rom J Morphol Embryol 55:965–971
Risselada M, Mathews KG, Griffith E (2015) Surgically planned versus histologically measured lateral tumor margins for resection of cutaneous and subcutaneous mast cell tumors in dogs: 46 cases (2010–2013). J Am Vet Med Assoc 247:184–189
Santoro M, Stacy BA, Morales JA, Gastezzi-Arias P, Landazuli S, Jacobson ER (2008) Mast cell tumour in a giant galapagos tortoise (geochelone nigra vicina). J Comp Pathol 138:156–159
Seibold HR, Wolf RH (1973) Neoplasms and proliferative lesions in 1065 nonhuman primate necropsies. Lab Anim Sci 23:533–539
Withrow SJ, David M (2007) Withrow and MacEwen's Small animal clinical oncology. 4th edn. Saunders Ltd, Arizona, pp 119–120
Yaqoob U, Bhandari S, Cheripalli P, Tangella K, Khaliq W (2014) Mastocytosis as an unusual cause of hip fracture in an elderly woman. WMJ 113:246–248
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Tsugo, K., Kinoshita, T., Kadowaki, K. et al. Subcutaneous malignant mast cell tumor in a Japanese macaque (Macaca fuscata). Primates 58, 19–23 (2017). https://doi.org/10.1007/s10329-016-0579-2
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DOI: https://doi.org/10.1007/s10329-016-0579-2