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Mechanisms of sinus node cycle length changes during ventricular fibrillation

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Abstract

Objective

We have previously shown that up to one-third of patients develop no change or an increase in sinus node cycle length (SNCL) during ventricular fibrillation (VF). The purpose of the present study was to investigate the mechanism of SNCL changes during VF in a swine model. We hypothesized that changes in SNCL during VF are vagally-mediated.

Methods

In 33 anesthetized pigs DC current was used to induce VF for 10 s followed by defibrillation. SNCL changes were assessed during VF and compared to baseline. Animals that had ventriculo-atrial conduction during VF were excluded. Post-defibrillation, the pigs were randomized to receive atropine, propranolol, atropine + propranolol or placebo followed by repeat VF induction and measurement of SNCL changes.

Results

Ventriculo-atrial conduction was present in 14 pigs prohibiting SNCL measurements. In the remaining 19 animals, 10 demonstrated SNCL shortening (S-Group) and 9 demonstrated non-shortening (NS-Group). Atropine decreased the absolute change in SNCL from 51.2 to 26.6 ms (n = 6; p = 0.03). It attenuated the SNCL shortening previously observed in the S-Group (−99.2 ms versus −47.9 ms, p = 0.04) and reversed the SNCL prolongation initially observed in the NS-Group (27.1 ms versus −6.5 ms, p = 0.13). Similarly, atropine + propranolol decreased the absolute change in SNCL from 33.3 to 12.2 ms (n = 4; p = 0.05). No significant changes were noted with propranolol or placebo.

Interpretation

The SNCL changes during VF appear to be vagally-mediated. The clinical implications vis-à-vis defibrillation threshold and future device programming await future studies.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, University of Wisconsin, H4/534 Clinical Science Center, 600 Highland Avenue, Madison, WI, 53792-3248, USA

    Stephen L. Wasmund, Richard L. Page & Mohamed H. Hamdan

  2. Department of Internal Medicine, University of Utah Health Sciences Center and Nora Eccles Harrison Cardiovascular Research and Training Institute, Salt Lake City, UT, 84112, USA

    Christina F. Pacchia

Authors
  1. Stephen L. Wasmund
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  2. Christina F. Pacchia
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  3. Richard L. Page
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  4. Mohamed H. Hamdan
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Correspondence to Mohamed H. Hamdan.

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Wasmund, S.L., Pacchia, C.F., Page, R.L. et al. Mechanisms of sinus node cycle length changes during ventricular fibrillation. Clin Auton Res 25, 399–406 (2015). https://doi.org/10.1007/s10286-015-0319-5

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  • DOI: https://doi.org/10.1007/s10286-015-0319-5

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