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P-wave duration and dispersion in children with uncomplicated familial Mediterranean fever

  • Original Article
  • Published:
Modern Rheumatology

Abstract

Objectives

This was a prospective controlled study to determine the P-wave duration (Pdu) and P-wave dispersion (Pd) in patients with familial Mediterranean fever (FMF).

Methods

The study group consisted of 26 children with uncomplicated FMF and 25 age- and sex-matched healthy controls. We performed electrocardiography (ECG) with Doppler echocardiography on patients and controls. All participants underwent 12-lead electrocardiography under strict standards. Pdu and Pd were computed from a randomly selected beat and from an averaged beat constructed from 12 beats, included in a 10-s ECG.

Results

The left ventricle (LV) dimensions, LV ejection fraction (LVEF), and LV fractional shortening (LVFS) values, left atrium dimension, and aortic dimension were in normal range in both groups. There were significant differences between the groups regarding LV-isovolumic relaxation time (IRT), LV-isovolumic contraction time (ICT), right ventricle (RV)-ICT, RV-IRT, and Pd (all p < 0.0001). However, highly significant positive correlation was detected between LV-ICT, LV-IRT, RV-ICT, RV-IVT, C-reactive protein (CRP), and Pd (r = 0.505, p < 0.0001; r = 0.483, p < 0.0001; r = 0.433, p = 0.001; r = 0.421, p = 0.001; r = 0.452, p = 0.001; r = 0.478, p < 0.0001, respectively).

Conclusions

Uncomplicated FMF children who are continuously treated with colchicine and do not develop amyloidosis have abnormal atrial dispersion and therefore seemingly have an increased electrocardiographic risk of atrial fibrillation.

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Conflict of interest

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Authors and Affiliations

  1. Department of Pediatric Cardiology, Selcuk University Faculty of Medicine, 42080, Konya, Turkey

    Derya Arslan, Bulent Oran & Derya Cimen

  2. Department of Pediatric Nephrology, Selcuk University Faculty of Medicine, Konya, Turkey

    Fatma Yazılıtas & Harun Peru

  3. Department of Biochemistry, Selcuk University Faculty of Medicine, Konya, Turkey

    Husamettin Vatansev

Authors
  1. Derya Arslan
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  2. Bulent Oran
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  3. Fatma Yazılıtas
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  4. Harun Peru
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  5. Derya Cimen
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  6. Husamettin Vatansev
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Corresponding author

Correspondence to Derya Arslan.

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Arslan, D., Oran, B., Yazılıtas, F. et al. P-wave duration and dispersion in children with uncomplicated familial Mediterranean fever. Mod Rheumatol 23, 1166–1171 (2013). https://doi.org/10.1007/s10165-012-0815-6

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  • DOI: https://doi.org/10.1007/s10165-012-0815-6

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