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Night-time blood pressure and pulse wave velocity in dialysis patients

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Abstract

Background

Ambulatory blood pressure (ABP) monitoring and carotid-femoral pulse wave velocity (cfPWV) provide important cardiovascular risk information for dialysis patients. This study aims to evaluate the risk factors of cfPWV and the associations between ambulatory blood pressure, especially night-time blood pressure and cfPWV.

Methods

We conducted a cross-sectional study in patients on maintenance hemodialysis. ABP and cfPWV were measured on a midweek interdialytic day. Associations were determined using Pearson’s correlation analysis and multiple stepwise regression model.

Results

Systolic BPs and pulse pressures, but not diastolic BPs, were significantly and positively associated with cfPWV. In a stepwise regression model, age, diabetes mellitus and all-period systolic BP were independently associated with cfPWV. When day-time and night-time BPs were included in the analysis, respectively, only night-time systolic BP and age remained as independently associated with cfPWV.

Conclusion

Ambulatory BPs are potent associates of cfPWV and night-time systolic BP, rather than day-time BPs, is an independently predictor of cfPWV. Our results support the view that controlling of nocturnal hypertension provides a unique cardiovascular protection effect.

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Acknowledgements

This work was supported by a grant from Science and Technology Bureau of Changzhou to Dr. Xiurong Li (Grant number CJ20160034).

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Author notes

  1. Xiurong Li, Qingbo Jiang and Wenhui Wu contributed equally to this work.

Authors and Affiliations

  1. Department of Hemodialysis, The Third Affiliated Hospital of Soochow University, Changzhou, China

    Xiurong Li, Wenhui Wu, Liying Miao, Lina Jin, Lina Xue, Tian Huang, Jia Di, Jinfeng Liu & Xiaozhou He

  2. Department of Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou, China

    Qingbo Jiang & Jinfeng Liu

  3. Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, China

    Xianlin Xu, Jinfeng Liu & Xiaozhou He

Authors
  1. Xiurong Li
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  2. Qingbo Jiang
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  3. Wenhui Wu
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  4. Xianlin Xu
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  5. Liying Miao
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  6. Lina Jin
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  7. Lina Xue
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  8. Tian Huang
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  9. Jia Di
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  10. Jinfeng Liu
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  11. Xiaozhou He
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Corresponding author

Correspondence to Xiaozhou He.

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No conflicting relationship exists for any author.

Ethical statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee at which the studies were conducted (Approval number 2015 Science 006).

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Cite this article

Li, X., Jiang, Q., Wu, W. et al. Night-time blood pressure and pulse wave velocity in dialysis patients. Clin Exp Nephrol 22, 173–178 (2018). https://doi.org/10.1007/s10157-017-1464-z

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  • DOI: https://doi.org/10.1007/s10157-017-1464-z

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