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Hemodiafiltration beneficially affects QT interval duration and dispersion compared to hemodialysis

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An Erratum to this article was published on 01 June 2014

Abstract

Background/aims

The prolongation of the QT interval and dispersion could predict ventricular arrhythmias. It is not yet established whether there is a difference between the effects of hemodialysis and hemodiafiltration on QT interval duration and dispersion.

Methods

Data of thirty patients was investigated while they were receiving hemodiafiltration over a period of 3 months; then the same group of patients was evaluated during treatment with conventional hemodialysis for at least another 3 months. Ionic parameters and surface electrocardiograms (ECG) were analyzed five times during each session, and 2D, M-mode echocardiography and Holter ECGs were performed to acquire additional information.

Results

QT interval duration (QTmax) and dispersion (QTd) showed a significant increase during hemodialysis, but not during hemodiafiltration. QTmax was 388.66 ± 31.81 ms at the beginning of hemodialysis and increased to 400.66 ± 39.12 ms even at the 30th minute (p < 0.05). QTd was found to be 31.33 ± 10.08 ms before the commencement of hemodialysis with the largest prolongation being seen at the 240th minute (51.33 ± 14.56 ms, p < 0.05). The occurrence of ventricular premature beats was significantly higher during hemodialysis (p = 0.018). The left atrial diameter significantly decreased at the end of hemodiafiltration (at the beginning 45.1 ± 5.25 mm, at the end 40.77 ± 5.76 mm; p < 0.05).

Conclusion

Our results suggest a beneficial effect of hemodiafiltration on the studied electrocardiographic parameters compared to hemodialysis. The larger decrease in the left atrial diameter suggests a more efficient intracardiac volume-decreasing potential of hemodiafiltration.

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Acknowledgments

Our research project was sponsored by the TÁMOP-4.2.2.A-11/1/KONV-2012-0045 project. This project is implemented through the New Hungary Development Plan, co-financed by the European Union and the European Social Fund.

Conflict of interest

None of the authors have relationship with companies that may have a financial or non-financial interest in the information contained in the manuscript.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, Medical and Health Science Centre, University of Debrecen, Pf. 19. Nagyerdei Krt. 98, Debrecen, 4012, Hungary

    Kitti Barta, Árpád Czifra, Alida Páll, Julianna Kulcsár, György Paragh, István Lőrincz, Tamás János Padra, József Balla & Zoltán Szabó

  2. Department of Cardiology, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary

    Csaba Kun

  3. Department of Medicine, Nephrology Research and Training Centre and Centre for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, USA

    Anupam Agarwal & Zarjou Abolfazl

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  1. Kitti Barta
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  2. Árpád Czifra
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  11. József Balla
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  12. Zoltán Szabó
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Correspondence to Zoltán Szabó.

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Barta, K., Czifra, Á., Kun, C. et al. Hemodiafiltration beneficially affects QT interval duration and dispersion compared to hemodialysis. Clin Exp Nephrol 18, 952–959 (2014). https://doi.org/10.1007/s10157-014-0950-9

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  • DOI: https://doi.org/10.1007/s10157-014-0950-9

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