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Serum albumin level accurately reflects antioxidant potentials in idiopathic nephrotic syndrome

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Abstract

Background

Recent observation revealed that serum albumin plays an important role in the host defense mechanism as it is one of the important antioxidants. This study was conducted to investigate whether hypoalbuminemia contributes to a decreased biological antioxidant potentials (BAP) in idiopathic nephrotic syndrome (INS).

Methods

Fifty three heparinised blood samples were obtained from 8 patients with INS (median 13.5 years). Eighteen samples from 6 patients with Henoch–Schönlein purpura (HSP median 7 years) were served as control. Intravenous human albumin preparation was also applied for comparison. Measurement of BAP in blood and human albumin preparation was determined by a newly developed devise called FRAS4®. Comparison among groups and relationships between BAP and albumin concentrations or c-reactive protein (CRP) were studied by Kruskal–Wallis test and Spearman rank correlation test, respectively.

Results

Serum levels of BAP was significantly lower in patients with nephrotic relapse than those in patients with nephrotic remission or HSP. BAP correlated well with serum albumin levels. Positive relationship was also found between concentration of albumin in human preparation and BAP. Weakly positive CRP sera disclosed both hypoalbuminemia and low BAP.

Conclusion

Our results suggest that decreased antioxidant potentials caused by hypoalbuminemia in INS may contribute to an aberrant immunity.

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References

  1. Eddy AA, Symons JM. Nephrotic syndrome in childhood. Lancet. 2003;362:629–39.

    Article  PubMed  Google Scholar 

  2. Hingorani SR, Weiss NS, Watkins SL. Predictors of peritonitis in children with nephrotic syndrome. Pediatr Nephrol. 2002;17:678–82.

    Article  PubMed  Google Scholar 

  3. Uncu N, Bülbül M, Yildiz N, Noyan A, Koşan C, Kavukçu S, et al. Primary peritonitis in children with nephrotic syndrome: results of a 5-year multicenter study. Eur J Pediatr. 2010;169:73–6.

    Article  PubMed  Google Scholar 

  4. Haynes GR, Navickis RJ, Wilkes MM. Albumin administration—what is the evidence of clinical benefit? A systematic review of randomized controlled trials. Eur J Anaesthesiol. 2003;20:771–93.

    Article  PubMed  CAS  Google Scholar 

  5. Chen TA, Tsao YC, Chen A, Lo GH, Lin CK, Yu HC, et al. Effect of intravenous albumin on endotoxin removal, cytokines, and nitric oxide production in patients with cirrhosis and spontaneous bacterial peritonitis. Scand J Gastroenterol. 2009;44:619–25.

    Article  PubMed  CAS  Google Scholar 

  6. Roche M, Rondeau P, Singh NR, Tarnus E, Bourdon E. The antioxidant properties of serum albumin. FEBS Lett. 2008;582:1783–7.

    Article  PubMed  CAS  Google Scholar 

  7. Nishikawa T, Okamoto Y, Kodama Y, Tanabe T, Shinkoda Y, Kawano Y. Serum derivative of reactive oxygen metabolites (d-ROMs) in pediatric hemato-oncological patients with neutropenic fever. Pediatr Blood Cancer. 2010;55:91–4.

    PubMed  Google Scholar 

  8. El-Melegy NT, Mohamed NA, Sayed MM. Oxidative modification of low-density lipoprotein in relation to dyslipidemia and oxidant status in children with steroid sensitive nephrotic syndrome. Pediatr Res. 2008;63:404–9.

    Article  PubMed  CAS  Google Scholar 

  9. Ece A, Atamer Y, Gürkan F, Davutolu M, Koçyiit Y, Tutanç M. Paraoxonase, total antioxidant response, and peroxide levels in children with steroid-sensitive nephrotic syndrome. Pediatr Nephrol. 2005;20:1279–84.

    Article  PubMed  Google Scholar 

  10. Karthikeyan K, Sinha I, Prabhu K, Bhaskaranand N, Rao A. Plasma protein thiols and total antioxidant power in pediatric nephrotic syndrome. Nephron Clin Pract. 2008;110:c10–4.

    Article  PubMed  CAS  Google Scholar 

  11. Dogra G, Ward N, Croft KD, Mori TA, Barrett PH, Herrmann SE, Irish AB, Watts GF. Oxidant stress in nephrotic syndrome: comparison of F(2)-isoprostanes and plasma antioxidant potential. Nephrol Dial Transpl. 2001;16:1626–30.

    Article  CAS  Google Scholar 

  12. Kamireddy R, Kavuri S, Devi S, Vemula H, Chandana D, Harinarayanan S, et al. Oxidative stress in pediatric nephrotic syndrome. Clin Chim Acta. 2002;325:147–50.

    Article  PubMed  CAS  Google Scholar 

  13. Natarajan SK, Mukhopadhya A, Ramachandran A, Amalanathan S, Kurian G, Balasubramanian KA. Spontaneous bacterial peritonitis results in oxidative and nitrosative stress in ascitic fluid. J Gastroenterol Hepatol. 2007;22:177–81.

    Article  PubMed  CAS  Google Scholar 

  14. Ramachandran A, Balasubramanian KA. Intestinal dysfunction in liver cirrhosis: its role in spontaneous bacterial peritonitis. J Gastroenterol Hepatol. 2001;16:607–12.

    Article  PubMed  CAS  Google Scholar 

  15. Mariano F, Tetta C, Montrucchio G, Cavalli PL, Camussi G. Role of alpha 1-proteinase inhibitor in restraining peritoneal inflammation in CAPD patients. Kidney Int. 1992;42:735–42.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgment

This study was partly supported by the Mami Mizutani Foundation.

Conflict of interest

None to declare.

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Authors and Affiliations

  1. Department of Pediatrics, Kansai Medical University, 2-3-l Shin-machi, Hirakata, Osaka, 573 1191, Japan

    Kazunari Kaneko, Takahisa Kimata, Shoji Tsuji, Tomohiko Shimo, Masaya Takahashi & Sachiyo Tanaka

Authors
  1. Kazunari Kaneko
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  2. Takahisa Kimata
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  3. Shoji Tsuji
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  4. Tomohiko Shimo
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  5. Masaya Takahashi
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  6. Sachiyo Tanaka
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Corresponding author

Correspondence to Kazunari Kaneko.

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Kaneko, K., Kimata, T., Tsuji, S. et al. Serum albumin level accurately reflects antioxidant potentials in idiopathic nephrotic syndrome. Clin Exp Nephrol 16, 411–414 (2012). https://doi.org/10.1007/s10157-011-0578-y

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  • DOI: https://doi.org/10.1007/s10157-011-0578-y

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