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A population-based study on the associations between chronic periodontitis and the risk of cancer

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Abstract

Background

To date, the associations between chronic periodontitis (CP) and cancer lack large-scale population-based epidemiological evidence. This study aimed to investigate the subsequent risk for cancers among subjects with CP.

Methods

This study cohort included 40,140 subjects with CP and 40,140 subjects who were matched for a comparison cohort. We individually tracked each patient for a 5-year period following their index date to identify those who had received a diagnosis of cancer.

Results

The incidence rate of cancer during the 5-year follow-up period was 14.80 (95 % CI 14.28–15.34) per 1,000 person-years in subjects with CP. Cox proportional hazards regression revealed that the hazard ratio of cancer during the 5-year follow-up period for subjects with CP was 1.23 (95 % CI 1.20–1.27) compared to that of the comparison cohort.

Conclusion

We observed an increased risk for the subsequent development of a number of cancers among subjects with CP.

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Author notes

    Authors and Affiliations

    1. Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao, Taipei, Taiwan

      Shiu-Dong Chung

    2. Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan

      Ming-Chieh Tsai

    3. School of Health Care Administration, Taipei Medical University, Taipei, Taiwan

      Chung-Chien Huang

    4. Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan

      Li-Ting Kao

    5. Department of Thoracic Surgery, Mackay Memorial Hospital, Taipei, Taiwan

      Chao-Hung Chen

    6. Mackay Medicine Nursing, and Management College, Taipei, Taiwan

      Chao-Hung Chen

    Authors
    1. Shiu-Dong Chung
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    2. Ming-Chieh Tsai
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    3. Chung-Chien Huang
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    4. Li-Ting Kao
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    5. Chao-Hung Chen
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    Corresponding author

    Correspondence to Li-Ting Kao.

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    The authors declare that they have no conflict of interest.

    Additional information

    L.-T. Kao and C.-H. Chen have equal contributions to this study.

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    Cite this article

    Chung, SD., Tsai, MC., Huang, CC. et al. A population-based study on the associations between chronic periodontitis and the risk of cancer. Int J Clin Oncol 21, 219–223 (2016). https://doi.org/10.1007/s10147-015-0884-6

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    • DOI: https://doi.org/10.1007/s10147-015-0884-6

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