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Evaluation of postoperative chemotherapy in patients with uterine carcinosarcoma: a retrospective survey of the Tohoku Gynecologic Cancer Unit

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Abstract

Background

The aim of this study was to evaluate prognostic factors including efficacy of postoperative chemotherapy in Japanese patients with uterine carcinosarcoma.

Methods

We conducted a retrospective survey of seven medical facilities in the Tohoku Gynecologic Cancer Unit.

Results

A total of 45 patients who had undergone hysterectomy and bilateral salpingo-oophorectomy were enrolled. No significant difference was observed in overall survival according to patient age (≤50 years vs >50 years) or retroperitoneal lymphadenectomy (performed vs. not performed). However, the International Federation of Gynecology and Obstetrics stage (stage I/II vs stage III/IV) and postoperative chemotherapy (provided vs not provided) were significant prognostic factors in both univariate and multivariate analyses for the 25-month median follow-up period.

Conclusions

Our results revealed that postoperative chemotherapy should be considered for all uterine carcinosarcoma stages in Japanese patients.

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Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan

    Ai Otsuki, Takeo Otsuki, Hideki Tokunaga, Hitoshi Niikura, Satoru Nagase, Takashi Sugiyama, Masafumi Toyoshima, Hiroki Utsunomiya, Tadao Takano, Yoh Watanabe & Nobuo Yaegashi

  2. Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

    Yoshihito Yokoyama & Hideki Mizunuma

  3. Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, Japan

    Naoki Sato & Yukihiro Terada

  4. Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan

    Tadahiro Shoji & Toru Sugiyama

  5. Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, Japan

    Kenji Nakahara & Tsuyoshi Ohta

  6. Department of Gynecology, Miyagi Cancer Center, Sendai, Japan

    Hidekazu Yamada & Toru Tase

  7. Department of Obstetrics and Gynecology, Fukushima Medical University, Fukushima, Japan

    Hiroshi Nishiyama & Keiya Fujimori

  8. Department of Clinical Research Network, Clinical Research, Innovation and Education Center, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan

    Tadao Takano, Fumiaki Takahashi & Yoh Watanabe

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  1. Ai Otsuki
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  2. Takeo Otsuki
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  3. Hideki Tokunaga
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  4. Hitoshi Niikura
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  7. Masafumi Toyoshima
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  8. Hiroki Utsunomiya
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  9. Yoshihito Yokoyama
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  10. Hideki Mizunuma
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  13. Tadahiro Shoji
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  15. Kenji Nakahara
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  16. Tsuyoshi Ohta
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  17. Hidekazu Yamada
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  18. Toru Tase
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  19. Hiroshi Nishiyama
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  20. Keiya Fujimori
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  21. Tadao Takano
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  22. Fumiaki Takahashi
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  23. Yoh Watanabe
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  24. Nobuo Yaegashi
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Corresponding author

Correspondence to Yoh Watanabe.

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Cite this article

Otsuki, A., Otsuki, T., Tokunaga, H. et al. Evaluation of postoperative chemotherapy in patients with uterine carcinosarcoma: a retrospective survey of the Tohoku Gynecologic Cancer Unit. Int J Clin Oncol 20, 574–578 (2015). https://doi.org/10.1007/s10147-014-0732-0

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  • DOI: https://doi.org/10.1007/s10147-014-0732-0

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