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Caffeine-potentiated chemotherapy for clear cell sarcoma: a report of five cases

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Abstract

Background

Clear cell sarcoma is a rare malignant tumor of soft tissue which is most commonly encountered in the extremities, especially in the foot and ankle. This tumor is slow-growing and looks like a benign tumor; it is therefore often treated inadequately and its high rate of recurrence and metastases results in a poor prognosis. Caffeine has been used as a chemotherapy potentiator that inhibits DNA damage repair and enhances the cytocidal effects of anti-cancer drugs. This study reports the effect of caffeine-potentiated chemotherapy for clear cell sarcoma in five patients.

Methods

Caffeine-potentiated chemotherapy was administered to five patients with clear cell sarcoma. Three to five courses of intra-arterial chemotherapy using cisplatin, doxorubicin and caffeine were administered preoperatively, at 3-week intervals. Conservatively, wide margin surgery was performed following the preoperative chemotherapy. Intravenous cisplatin and doxorubicin with caffeine were administered three to six times to the patients who responded to the preoperative chemotherapy. This study evaluated the response to chemotherapy, recurrence, metastasis and the overall prognosis in these five patients.

Results

Four of the eligible patients responded to preoperative chemotherapy. Local recurrence occurred in only one of the five patients. Distant metastasis newly developed in one patient. All five patients survive.

Conclusion

Caffeine-potentiated chemotherapy can be effective treatment for clear cell sarcoma not only as initial therapy, but also as salvage therapy.

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Conflict of interest

No author has any conflict of interest.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Koseiren Namerikawa Hospital, 119 Tokiwa-cho, Namerikawa, 936-8585, Japan

    Michiaki Karita

  2. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan

    Michiaki Karita, Hiroyuki Tsuchiya, Norio Yamamoto, Toshiharu Shirai, Katsuhiro Hayashi & Hideji Nishida

Authors
  1. Michiaki Karita
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  2. Hiroyuki Tsuchiya
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  3. Norio Yamamoto
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  4. Toshiharu Shirai
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  5. Katsuhiro Hayashi
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  6. Hideji Nishida
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Corresponding author

Correspondence to Hiroyuki Tsuchiya.

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Karita, M., Tsuchiya, H., Yamamoto, N. et al. Caffeine-potentiated chemotherapy for clear cell sarcoma: a report of five cases. Int J Clin Oncol 18, 33–37 (2013). https://doi.org/10.1007/s10147-011-0337-9

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  • DOI: https://doi.org/10.1007/s10147-011-0337-9

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