Abstract
Central neurocytomas are low grade tumours usually located in the lateral ventricles next to Monro foramina. This paper reviews the literature on central neurocytomas observed in the last few years and discusses their clinical, histopathological, immunohistochemical and genetic characteristics. Important correlations between therapeutic strategies and biological findings as well as new genetic discoveries are also discussed. Two illustrative cases in which the authors report preliminary results about molecular analysis of some genetic markers are described.
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Anderson RC, Elder JB, Parsa AT et al (2001) Radiosurgery for the treatment of recurrent central neurocytomas. Neurosurgery 48:1231–1238
Ashkan K, Casey AT, D’Arrigo C, Harkness WF, Thomas DG (2000) Benign central neurocytoma. Cancer 89:1111–1120
Bertalany A, Roessler K, Dietrich W, Aichholzer M, Prayer D, Ertl A et al (2001) Gamma knife radiosurgery of recurrent central neurocytomas: a preliminary report. J Neurol Neurosurg Psychiatry 70:489–493
Brandles AA, Amista P, Gardiman M et al (2000) Chemotherapy in patients with recurrent and progressive central neurocytoma. Cancer 88:169–174
Brat DJ, Scheithauer BW, Eberhart CG, Burger PC (2001) Extraventricular neurocytoma: pathologic features and clinical outcome. Am J Surg Pathol 25:1252–1260
Cobery ST, Norren G, Friehs GM et al (2001) Gamma Knife surgery for treatment of central neurocytoma. J Neurosurg 94:327–330
Dodds D, Nonis J, Mehta M, Rampling R (1997) Central neurocytoma: a clinical study of response to chemotherapy. J Neurooncol 34:279–283
Dodero F, Alliez JR, Metellus P, Hassan H, Hassoun J, Alliez B (2000) Central neurocytoma: 2 case reports and review of the literature. Acta Neurochir (Wien) 142:1417–1422
Elek G, Slowik K, Eross L, Toth S, Szabò Z, Balint K (1999) Central neurocytoma with malignant course. Pathol Oncol Res 5:155–159
Eng DY, De Monte F, Ginsberg L, Fuller G, Jaeckle K (1997) Craniospinal dissemination of central neurocytoma. J Neurosurg 86:547–552
Figarella-Branger D, Pellissier JF, Daumas-Duport C, Delisle MB, Pasquier B, Parent M et al (1997) Central neurocytoma. Critical evaluation of a small-cell neuronal tumor. Am J Neurooncol 32 :103–109
Figarella-Branger D, Pellissier JF, Daumas-Duport C, Delisle MB, Pasquier B, Parent M et al (1992) Central neurocytomas. Critical evaluation of a small-cell neuronal tumor. Am J Surg Pathol 16:97–109
Figarella-Branger D, Soylemezoglu F, Kleihues P, Hassoun J (2000) Central neurocytoma In: Kleihues P Cavenee WK, editors. Pathology and genetics of tumors of the central nervous system. World Health Organization classification of tumours. IARC Press, Lyon, pp 107–111
Fujimaki T, Matsuno A, Sasaki T, Toyoda T, Matsuura R, Ogai M et al (1997) Proliferative activity of central neurocytoma: measurement of tumor volume doubling time, MIB-1 staining index and bromodeoxyuridine labeling index. J Neurooncol 32:103–109
Fujisawa H, Marukawa K, Hasegawa M et al (2002) Genetic differences between neurocytoma and dysembrioblastic neuroepithelial tumor and oligodendroglial tumors. J Neurosurg 97:1350–1355
Giangaspero F, Cenacchi G, Losi L, Cesaroli S, Bisceglia M, Burger PC (1997) Extraventricular neoplasms with neurocytoma features. A clinicopathological study of 11 cases. Am J Surg Pathol 21:206–212
Goergen SK, Gonzales MF, McLean CA (1992) Intraventricular neurocytoma: radiologic features and review of the literature. Radiology 182:787–792
Hara M, Aoyagi M, Yamamoto M et al (2003) Rapid shrinkage of remnant central neurocytoma after gamma knife radiosurgery: a case report. J Neuro-Oncol 62:269–273
Hassoun J, Gambarelli D, Grisoli F et al (1982) Central Neurocytoma. An electron-microscopic study of two cases. Acta Neuropathol (Berl) 56:151–156
Jamshidi J, Izumoto S, Yoshime T, Maruno M (2001) Central Neurocytoma presenting with intratumoral haemorrhage. Neusrosurg Rev 24:48–52
Kawashima M, Suzuki SO, Don-ura K et al (2000) Alpha-Synuclein is expressed in a variety of brain tumors showing neuronal differentiation. Acta Neuropathol 99:154–160
Kim DG, Paek SH, Kim IH et al (1997) Central neurocytoma: the role of radiation therapy and long term outcome. Cancer 79:1995–2002
Koeller KK, Sandberg GD (2002) From the archives of the AFIP. Cerebral intraventricular neuroplasms: radiologic-pathologic correlation. Radiographics 22:1473–1505
Kubota T, Hayashi M, Kawano H, Kabuto M, Sato K, Ishise J et al (1991) Central neurocytoma: immunohistochemical and ultrastructural study. Acta Neuropathol (Berl) 81:418–427
Kulkarni V, Rajshekhar V, Haran RP, Chandi SM (2002) Long-term outcome in patients with central neurocytoma following stereotactic biopsy and radiation therapy. Br J Neurosurg 16:126–132
Kusama H, Kohda T, Itoh YM, Miwa T, Hokano M (1988) A case of central neurocytoma. J Clin Electron Microsc 21834–21835
Lee HY, Chuah KL, Chan LP (2002) An intraventricular brain tumor in a young woman. Part 1. Central neurocytoma. Pathology 34:185–188
Lee J, Chang S, McDermott MW, Parsa AT (2003) Intraventricular neurocytomas. Neurosurg Clin N Am 14:483–508
Leung SY, Ng HK, Pang JC et al (1996) Three recently recognized tumors that may mimic oligodendroglioma: central neurocytoma, dysembrioblastic neuroepithelial tumor and clear celle ependymoma. Adv Anat Pathol 3:130–138
Louis DN, Swearingen B, Linggood RM, Dickersin GR, Kretschmar C, Bhan AK et al (1990) Central nervous system neurocytoma and neuroblastoma in adults-report of 8 cases. J Neurooncol 9:231–238
Luxton G, Petrovich Z, Jozsef G, Nezdi LA, Apuzzo ML (1992) Stereotactic radiosurgery: principles and comparison of treatment methods. Neurosurgery 32:241–259
Mackenzie IR (1999) Central neurocytoma: histologic atypia, proliferation potential and clinical outcome. Cancer 85:1606–1610
Maiuri F, Spaziante R, De Caro ML, Cappabianca P, Giamundo A, Iaconetta G (1995) Central neurocytoma: clinico-pathological study of 5 cases and review of the literature. Clin Neurol Neurosurg 97:219–228
Metellus P, Alliez JR, Doderot F, Hassoun J, Alliez B (2000) Central neurocytoma: 2 case report and review of the literature. Acta Neurochir (Wien) 142:1417–1422
Mineura K, Sasajima T, Itoh Y, Sasajima H, Kowada M, Tomura N et al (1995) Blood flow and metabolism of central neurocytoma: a positron emission tomography study. Cancer 76:1224–1232
Moller-Hartmann W, Krings T, Brunn A, Korinth M, Thron A (2002) Proton magnetic resonance spectroscopy of neurocytoma outside the ventricular region. Case report and review of the literature. Neuroradiology 44:230–234
Nishio S, Morioka T, Suzuki S, Fukui M (2002) Tumours around the foramen of Monro: clinical and neuroimaging features and their differential diagnosis. J Clin Neurosci 9:137–141
Nishio S, Tashima T, Takeshita I, Fukui M (1988) Intraventricular neurocytoma: clinicopathological features of six cases. J Neurosurg 68:665–670
Perry NG, Sun Soo Y, Chaseling R, O’Neil P (1996) Intraventricular neurocytoma. Australian Radiology 40:125–133
Rades D, Fehlauer F (2002) Treatment options for central neurocytoma. Neurology 59:1268–1270
Rades D, Fehlauer F, Schild SE (2004) Treatment of atypical neurocytoma. Cancer 15:814–817
Robbins P, Segal A, Narula S, Stokes B, Lee M, Thomas W et al (1996) Central neurocytoma. A clinico-pathological, immunohistochemical and ultrastructural study of 7 cases. Pathol Res Radiol 191:100–111
Ron E, Modan B, Boice JD, Alfandary E, Stovall M, Chetrit A et al (1988) Tumors of the brain and nervous system after radiotherapy in childhood. N Engl J Med 319:1033–1039
Schild SE, Scheithauer BW, Haddock MG et al (1997) Central neurocytomas. Cancer 79:790–795
Schweitzer JB, Davies KG (1997) Differentiating central neurocytoma. J Neurosurg 86:543–546
Sgouros S, Carey M, Aluwihare N, Barber P, Jackowski A (1998) Central neurocytoma: a correlative clinico–pathologic and radiologic analysis. Surg Neurol 49:197–204
Sgouros S, Walsh R, Barber P (1994) Central neurocytoma of thalamic origin. Br J Neurosurg 8373–8376
Smoker WR, Townsend JJ, Reichman MV (1991) Neurocytoma accompained by intraventricular haemorrhage: case report and literature review. Am J Neuro Radiol (AJNR) 12:765–770
Soontornniyomkij V, Schelper RI (1996) Pontine neurocytoma. J Clin Pathol 49:764–770
Soylemezoglu F, Scheithauer BW, Esteve J, Kleihues P (1997) Atypical central neurocytoma. J neuropathol Exp Neurol 56:551–556
Taruscio D, Danesi R, Montaldi A et al (1997) Nonrandom gain of chromosome 7 in central neurocytoma: a chromosomal analysis and fluorescence in situ hybridization study. Virchows Archiv 430:47–51
Tatter SB, Borges LF, Louis DN (1994) Central neurocytoma of the cervical spinal cord. Report of two cases. J Neurosurg 81:288–293
Tong CY, Ng HK, Pang JC et al (2000) Central neurocytomas are genetically distinct from oligodendrogliomas and neuroblastoma. Histopathology 37:160–165
Tyler-Kabara E, Kondziolka D, Flickinger JC, Lunsford LD (2001) Stereotactic radiosurgery for residual neurocytoma. Report of four cases. J Neurosurg 95:879–882
Valdueza JM, Westphal M, Vortmeyer A, Muller D, Padberg B, Herrmann HD (1996) Central neurocytoma: clinical, immunohistologic, and biologic findings of a human neuroglial progenitor tumor. Surg Neurol 45:49–56
von Deimling A, Kleihues P, Saremaslani P et al (1991) Histogenesis and differentiation potential of central neurocytomas. Lab Invest 64:585–591
Von Deimling A, Panzer R, Kleihues P, Wiestler OD (1990) Patterns of differenziation in central neurocytoma: an immunohistochemical study of eleven biopsies. Acta Neuropathol 79:473–479
von Koch CS, Schmidt MH, Uyehara-Lock JH, Berger MS, Chang SM. (2003) The role of PCV chemotherapy in the treatment of central neurocytoma: illustration of a case and review of the literature. Surg Neurol 60:560–565
Waldron JS, Tihan T (2003) Epidemiology and pathology of intraventricular tumors. Neurosurg Clin N Am 14(4):469–482
Yasargil MG, von Ammon K, von Deimling A, Valavanis A, Wichmann W, Wiestler OD (1992) Central neurocytoma: histopathological variants and therapeutics approaches. J Neurosurg 76:32–37
Yin XL, Pang JC, Hui AB, Ng HK (2000) Detection of chromosomal imbalance in central neurocytoma by using comparative genomic hybridization. J Neurosurg 93:77–81
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De Tommasi, A., D’Urso, P.I., De Tommasi, C. et al. Central neurocytoma: two case reports and review of the literature. Neurosurg Rev 29, 339–347 (2006). https://doi.org/10.1007/s10143-006-0041-9
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DOI: https://doi.org/10.1007/s10143-006-0041-9