Abstract
The results of differences of wool oxygen status of healthy and cancer carrier mice with spontaneous cancer tumor are represented herein. The investigation was carried out by electronic microscopy and laser-flash photolysis. In the work, two types of breast tumors were researched. Small tumor (nearly 0.5 ÷ 1 cm) was detected by palpation and was well encapsulated. Large tumor was operated when tumor had been disintegrated. It is shown that wool of healthy mouse has dense structure; external layer with large scales is pronounced. At the time, wool of mice with cancer tumor is thinner; external and internal layers are destroyed. Length of scales is shorter. There is difference even when tumor diameter is small. Oxygen concentration increases for cancer present, and it is related to reactive oxygen species rising within external layer. Reactive oxygen species have most distribution in general oxygen concentration in external cell layer. At the time, its increase in internal layer is insignificant. The obtained results can be used to improve optical techniques of biomedical diagnostics of cancer diseases.
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Acknowledgments
The work was partially supported by grant of the Ministry of Science and Education of Russian Federation № 450 from 01.02.2014 and RF president scholarship SP-273.2015.4.
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Maryakhina, V.S., Ovechkin, M.V. Changes of oxygen status of hair cells for breast cancer presence. Lasers Med Sci 31, 979–983 (2016). https://doi.org/10.1007/s10103-016-1943-6
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DOI: https://doi.org/10.1007/s10103-016-1943-6