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Can we predict the outcome of 595-nm wavelength pulsed dye laser therapy on capillary vascular malformations from the first beginning: a pilot study of efficacy co-related factors in 686 Chinese patients

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Abstract

Currently, there are no standardized, objective, and clinically applicable methods to predict the outcome of pulsed dye laser (PDL) therapy on capillary vascular malformation (CVM) patients. The introduction of a method that can predict the outcome prior to treatment will be valuable for both the patients and the doctors. In this study, the authors treated CVM with 595-nm wavelength PDL in Chinese patients (n = 686) and analyzed the efficacy of treatment and complications retrospectively in a 5-year period. Nearly 18 % of patients (n = 122) had 76 % or more clearing of lesions; over 52 % of patients (n = 360) had more than 50 % of clearing. The lesions in head and neck region had the best effective rate (58.3 %), followed by trunk (42.9 %) and extremities (35.6 %). The efficacy of PDL therapy is related to age, type, and location of lesions. Fifty-seven patients (8.3 %) had complications, including 2.0 % blistering (n = 14), 4.5 % hyperpigmentation (n = 31), 1.3 % hypopigmentation (n = 9), and 0.4 % hypertrophic scarring (n = 3). Based on these preliminary data, the authors established a standardized, objective, and clinically applicable equation that may be applied to predict the efficacy of 595 nm PDL therapy on a newly diagnosed Chinese CVM patients based on the age, type, and location of lesions.

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The authors have no conflicts of interest to declare and no funding was received.

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Authors and Affiliations

  1. Division of Plastic and Reconstructive Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China

    Xiangxia Liu & Ruixi Zeng

  2. Department of Aesthetic and Laser Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China

    Xiangxia Liu, Yanfang Fan, Ruixi Zeng, Guangling Cao, Mukai Chen, Wenna Chen & Jinming Tang

  3. Department of Radiology, Guangdong Provincial Hospital of Chinese Traditional Medicine, Guangzhou, 510120, China

    Jiexin Huang

  4. Department of Dermatology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China

    Guangling Cao, Mukai Chen & Wenna Chen

  5. Division of Burn Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China

    Jinming Tang

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  1. Xiangxia Liu
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Correspondence to Xiangxia Liu.

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Liu, X., Fan, Y., Huang, J. et al. Can we predict the outcome of 595-nm wavelength pulsed dye laser therapy on capillary vascular malformations from the first beginning: a pilot study of efficacy co-related factors in 686 Chinese patients. Lasers Med Sci 30, 1041–1046 (2015). https://doi.org/10.1007/s10103-014-1695-0

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  • DOI: https://doi.org/10.1007/s10103-014-1695-0

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