Abstract
The purpose of this study was to describe the variation in listeriosis infection incidence during pregnancy over a 25-year period based on salient clinical and laboratory features compiled in a tertiary referral hospital and to depict the clinical characteristics of these cases. A cohort was created of all cases of listeriosis in pregnant women or their neonates (early-onset form) diagnosed between 1985 and 2010. Forty-three cases of perinatal listeriosis were diagnosed among the 82,320 hospitalised pregnant women (incidence 0.5‰). Whereas the incidence remained almost constant at 0.24‰ until 2000, an increasing incidence was observed from then on, reaching 0.86‰ during the last years of the study period. A four-fold increase in listeriosis rate during pregnancy has occurred in recent years, with poorer outcome for those cases occurring before 28 weeks and for those in which early antibiotic treatment was not provided. These results should raise the awareness of the agencies and professionals involved in prenatal care.
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References
CDC (2010) Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food - 10 states, 2009. Centers for Disease Control and Prevention (CDC). MMWR Morb Mortal Wkly Rep 59(14):418
Voetsch AC, Angulo FJ, Jones TF, Moore MR, Nadon C, McCarthy P et al (2007) Reduction in the incidence of invasive listeriosis in foodborne diseases active surveillance network sites, 1996-2003. Clin Infect Dis 44:513–520
CDC (2010) Annual epidemiological report on communicable diseases in Europe 2010. European Centre for Disease Prevention and Control, Solna, Sweden
CDC (2009) Annual epidemiological report on communicable diseases in Europe 2009, revised edition. European Centre for Disease Prevention and Control, Solna, Sweden
Leber A, Zenclussen ML, Teles A, Brachwitz N, Casalis P, El-Mousleh T et al (2011) Pregnancy: Tolerance and suppression of immune responses. Methods Mol Biol 677:397–417
Redline RW, Lu CY (1988) Specific defects in the anti-listerial immune response in discrete regions of the murine uterus and placenta account for susceptibility to infection. J Immunol 140:3947–3955
Southwick FS, Purich DL (1996) Intracellular pathogenesis of listeriosis. N Engl J Med 334:770–776
Mylonakis E, Paliou M, Hohmann EL, Calderwood SB, Wing EJ (2002) Listeriosis during pregnancy: A case series and review of 222 cases. Med Baltim 81:260–269
Posfay-Barbe KM, Wald ER (2009) Listeriosis. Semin Fetal Neonatal Med 14(4):228–233
Brunet O, Lèzine L (1955) Echelle de développment psychologique de la prèmiere enfance Manuel d’instruction [Scale development project of the first psychological children's instruction manual]. Editions Scientifiques et Psychotechniques, Clamart, Seine
Antal EA, Hogasen HR, Sandvik L, Maehlen J (2007) Listeriosis in Norway 1977-2003. Scand J Infect Dis 39:398–404
Kasper S, Huhulescu S, Auer B, Heller I, Karner F, Wurzner R et al (2009) Epidemiology of listeriosis in Austria. Wien Klin Wochenschr 121:113–119
Goulet V, Hedberg C, Le Monnier A, de Valk H (2008) Increasing incidence of listeriosis in France and other European countries. Emerg Infect Dis 14:734–740
López LGL, Martínez I, Aguirrebengoa K, Valls A, Hernández JL, Alkorta M et al (2007) Listeriosis. Estudio de 16 años en un hospital terciario en España [Listeriosis. 16-year study in a tertiary hospital in Spain]. Rev Panam Infectol 9(2):30–37
Koch J, Stark K (2006) Significant increase of listeriosis in Germany—epidemiological patterns 2001–2005. Euro Surveill 11:85–88
Gillespie IA, McLauchlin J, Grant KA, Little CL, Mithani V, Penman C et al (2006) Changing pattern of human listeriosis, England and Wales, 2001–2004. Emerg Infect Dis 12:1361–1366
Carrasco E, Pérez-Rodríguez F, Valero A, García-Gimeno RM, Zurera G (2007) Survey of temperature and consumption patterns of fresh-cut leafy green salads: risk factors for listeriosis. J Food Prot 70(10):2407–2412
Nolla-Salas J, Bosch J, Gasser I, Viñas L, de Simon M, Almela M et al (1998) Perinatal listeriosis: A population-based multicenter study in Barcelona, Spain (1990–1996). Am J Perinatol 15:461–467
Craig S, Permezel M, Doyle L, Mildenhall L, Garland S (1996) Perinatal infection with Listeria monocytogenes. Aust NZ J Obstet Gynaecol 36:286–290
Cruikshank DP, Warenski JC (1989) First-trimester maternal Listeria monocytogenes sepsis and chorioamnionitis with normal neonatal outcome. Obstet Gynecol 73:469–471
Cairns BJ, Payne RJ (2009) Sudden increases in listeriosis rates in England and Wales, 2001 and 2003. Emerg Infect Dis 15:465–468
Fleming AD, Ehrlich DW, Miller NA, Monif GR (1985) Successful treatment of maternal septicemia due to Listeria monocytogenes at 26 weeks' gestation. Obstet Gynecol 66:52S–53S
Yu VL, Miller WP, Wing EJ, Romano JM, Ruiz CA, Bruns FJ (1982) Disseminated listeriosis presenting as acute hepatitis. Case reports and review of hepatic involvement in listeriosis. Am J Med 73:773–777
Allerberger F, Wagner M (2010) Listeriosis: a resurgent infection. Clin Microbiol Infect 16(1):16–23
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We thank the Hospital obgyn residents, neonatologists and microbiologists for collecting patient data and processing the samples.
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Sisó, C., Goncé, A., Bosch, J. et al. Listeriosis in pregnancy: a secular trend in a tertiary referral hospital in Barcelona. Eur J Clin Microbiol Infect Dis 31, 2125–2132 (2012). https://doi.org/10.1007/s10096-012-1545-6
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DOI: https://doi.org/10.1007/s10096-012-1545-6