Abstract
Presented here are the results of a retrospective analysis of all mucormycoses infections recorded at a tertiary hospital in Greece during the last 10 years. A total of 24 patients were identified, 15 male and 9 female, with ages ranging from 37 to 80 years. Twelve of the patients had soft tissue infections (2 with concomitant pulmonary infections), and 12 had rhinocerebral infections. Transmission could be traced in two cases; to nitroglycerin patches in one patient and to a lemon-tree-thorn scratch in the other. Among the 17 patients who underwent surgery, 11 survived. All seven patients on whom surgery was not performed died. Rapid diagnosis and treatment of mucormycosis are essential for patient survival. The severity of the patient’s underlying condition, the degree of immunosuppression, and prompt surgical treatment are the most important factors contributing to the outcome.
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References
Ribes JA, Vanover-Sams CL, Baker DJ (2000) Zygomycetes in human disease. Clin Microbiol Rev 13:236–301
Lueg EA, Ballagh RH, Forte V (1996) Analysis of the recent cluster of invasive fungal sinusitis at the Toronto Hospital for Sick Children. J Otolaryngol 25:366–370
Sugar AM (1992) Mucormycosis. Clin Infect Dis 14 (Suppl 1):126–129
Adam RD, Hunter G, DiTomasso J, Comerci G (1994) Mucormycosis: emerging prominence of cutaneous infections. Clin Infect Dis 19:67–76
Mead JH, Lupton GP, Dillavou CL, Odom RB (1979) Cutaneous Rhizopus infection: occurrence as a postoperative complication associated with an elasticized adhesive dressing. JAMA 242:272–274
Jain JK, Markowitz A, Khilanani PV (1978) Case report: localized mucormycosis following intramuscular corticosteroid, case report and review of the literature. Am J Med Sci 275:209–216
Chinn RY, Diamond RD (1982) Generation of chemotacticfactors by Rhizopus oryzae in the presence and absence of serum: relationship to hyphal damage mediated by human neutrophils and effects of hyperglycemia and ketoacidosis. Infect Immun 38:1123–1129
Fisher J, Tuazon CU, Geelhoed GW (1980) Mucormycosis in transplant patients. Am Surg 46:315–322
Thompson AW, Moon DK, Geczy CL, et al. (1983) Cyclosporin A inhibits lymphokine production but not the responses of macrophages to lymphokines. Immunology 48:291–299
Bigby TD, Serola ML, Tierny LM, Matthay MA (1986) Clinical spectrum of pulmonary mucormycosis. Chest 89:435–439
Tojima H, Tokudome T, Otsuka T (1997) Chronic pulmonary mucormycosis that developed in preexisting cavities caused by tuberculosis in a patient with diabetes mellitus and liver cirrhosis. Nihon Kyobu Shikkan Gakkai Zasshi 35:100–105
Radner AB,Witt MD, Edwards Jr JE (1995) Acute rhinocerebral zygomycosis in an otherwise healthy patient: case report and review. Clin Infect Dis 20:163–166
Ng TT, Campbell CK, Rothera M, Houghton JB, Hughes D, Denning DW (1994) Successful treatment of sinusitis caused by Cunninghamella bertholletiae. Clin Infect Dis 19:313–316
Tomford JW, Whittlesey D, Ellner JJ, Tomashefski Jr JF (1980) Invasive primary cutaneous phycomycosis in diabetic leg ulcers. Arch Surg 115:770–771
Kontoyannis DP, Wessel VC, Bodey GP, Rolston KV (2000) Zygomycosis in the 1990s in a tertiary-care cancer center. Clin Infect Dis 30:851–856
Kotzamanoglou K, Tzanakakis G, Michalopoulos E, Stathopoulou M (1988) Orbital cellulites due to mucormycosis. A case report. Graefes Arch Clin Exp Opthalmol 226:539–541
Economopoulou P, Laskaris G, Ferekidis E, Kanelis N (1995) Rhinocerebral mucormycosis with severe oral lesions: a case report. J Oral Maxillofac Surg 53:215–217
Athanasiou E, Barbanis S, Kostopoulos L, Kaloutsi V, Zois E, Ageloudi M, Malaka A, Papadimitriou C (1998) Opportunistic infections in immunosuppressed/immunodeficient patients: a histological and immunohistochemical study in three cases. Arch Hellenic Pathol 12:116–121
Kanellopoulou M, Velegraki A, Mylona E, Papaefstathiou K, Legakis N, Papafrangas E (1999) Cutaneous Rhizopus oryzae mucormycosis. Archi Hellenic Med 16:383–385
Papadogeorgakis N, Logothetis I, Marti-Zografou K, Rondogianni D, Foundas A, Chalevelakis G, Raptis SA (1999) Late surgical intervention in a diabetic patient with mucormycosis of the head and neck, after prolonged treatment with liposomal amphotericin B. Arch Hellenic Med 16:496–500
Tsaousis G, Koutsouri A, Gatsiou C, Paniara O, Peppas C, Chalevelakis G (2000) Liver and brain mucormycosis in a diabetic patient type II successfully treated with liposomal amphotericin B. Scand J Infect Dis 32:335–337
Tsoutsos D, Tsati E, Metaxotos N, Keramidas E, Rodopoulou S, Ioannovich J (2001) Extensive burn injury complicated by mucormycosis: a case report. Ann Burn Fire Disasters XIV(3)
Papadaki TH, Mastrodimos V, Tsilimbaris M, Pallikaris J (2001) Orbital mucormycosis Iatriki 79:74–78
Tryfon S, Stanopoulos I, Kakavelas E, Nikolaidou A, Kioumis I (2002) Rhinocerebral mucormycosis in a patient with latent diabetes mellitus: a case report. J Oral Maxillofac Surg 60:328–330
Kyrmizakis DE, Doxas PG, Hajiioannou JK, Papadakis CE (2002) Palate ulcer due to mucormycosis. J Laryngol Otol 116:146–147
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Petrikkos, G., Skiada, A., Sambatakou, H. et al. Mucormycosis: Ten-Year Experience at a Tertiary-Care Center in Greece. Eur J Clin Microbiol Infect Dis 22, 753–756 (2003). https://doi.org/10.1007/s10096-003-1035-y
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DOI: https://doi.org/10.1007/s10096-003-1035-y