Abstract
The objective was to determine plasma levels of pro- (IL-12p70/IL-6) and anti-inflammatory (IL-10) cytokines before and after cycle ergometer training in healthy control (HC) and people with multiple sclerosis (pwMS), and to correlate plasma cytokines with physical/mental health. Study participants cycled for 30 min at 65–75% age-predicted maximal heart rate, twice a week for 8 weeks during supervised sessions. We determined that plasma IL-10 expression was lower in pwMS, compared to HCs, and that exercise augmented IL-10 in pwMS to baseline levels in HCs. Furthermore, plasma isolated from pwMS displayed enhanced expression of the pro-inflammatory cytokines IL-12p70/IL-6. Plasma cytokine signatures correlated with physical/mental health. Overall, this study highlights the potential of a short-term exercise programme to regulate circulating cytokine profiles with relevance to pwMS.
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Change history
21 May 2019
Following publication the authors informed the Journal that the published version of this article contained a mistake. All occurrences of pg/μl found in the original article should be changed to pg/L. The original article has been corrected. The correction has no impact on the conclusions drawn in the manuscript.
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Acknowledgements
AB was supported by the Department of Physiology, UCC. The authors thank all participating subjects in this study.
Funding
The study receives grant support from the Physiological Society (to EJD), the UCC School of Medicine Translational Research Access Programme (to EJD and OOT) and the UCC Strategic Research Fund (to EJD towards purchase of a recumbent ergometer).
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The original version of this article was revised: The published version of this article unfortunately contained a mistake. All occurrences of pg/μl found in the original article should be change to pg/L
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Barry, A., Cronin, O., Ryan, A.M. et al. Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis. Neurol Sci 40, 1933–1936 (2019). https://doi.org/10.1007/s10072-019-03915-2
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DOI: https://doi.org/10.1007/s10072-019-03915-2