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A case of medulloblastoma in adult patient affected by anaplastic oligoastrocytoma

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Abstract

Medulloblastomas and high-grade gliomas (HGG) are two distinct brain tumor, with different peculiarities in terms of age of onset, localizations and prognosis. The coexistence of the two neoplasms in the same adult patient is an extremely rare event. We present the case of a woman treated with radio-chemotherapy for an HGG, who developed a cerebellar medulloblastoma 7 years later. Considering the poor prognosis of these tumors, the lack of knowledge about the mechanisms of onset as well as effective therapies, it is necessary to determine the exact role of irradiation and the presence of any potential molecular genetic abnormalities in the developing of the two tumors.

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Authors and Affiliations

  1. Neuro Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy

    G. Simonetti, Paola Gaviani, E. Lamperti, A. Innocenti, A. Botturi & A. Silvani

  2. Neurosurgery Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

    M. Saini

  3. Neuropathology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

    B. Pollo

Authors
  1. G. Simonetti
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  2. Paola Gaviani
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  3. E. Lamperti
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  4. A. Innocenti
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  5. A. Botturi
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  6. M. Saini
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  7. B. Pollo
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  8. A. Silvani
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Correspondence to Paola Gaviani.

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Simonetti, G., Gaviani, P., Lamperti, E. et al. A case of medulloblastoma in adult patient affected by anaplastic oligoastrocytoma. Neurol Sci 37, 1727–1730 (2016). https://doi.org/10.1007/s10072-016-2640-8

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  • DOI: https://doi.org/10.1007/s10072-016-2640-8

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